Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27745218 | 0.83 | MEN1 (0.45) | MEN1KMT2AFAAHSLC6A9HDAC6 | |
| SCHEMBL27745176 | 0.83 | MEN1 (0.45) | MEN1KMT2AFAAHSLC6A9HDAC6 | |
| SCHEMBL5910308 | 0.83 | MEN1 (0.45) | MEN1KMT2AFAAHSLC6A9HDAC6 | |
| Propane SCHEMBL7390979 | 0.81 | MEN1 (0.44) | MEN1KMT2AFAAHSLC6A9HDAC6 | |
| SCHEMBL18355944 | 0.78 | MEN1 (0.42) | MEN1KMT2AFAAHSLC6A9HDAC6 | |
| SCHEMBL10287179 | 0.77 | LMNA (0.48) | MEN1KMT2ALMNAALDH1A1TDP1 | |
| SCHEMBL19286308 | 0.77 | LMNA (0.48) | MEN1KMT2ALMNAALDH1A1TDP1 | |
| SCHEMBL28246465 | 0.75 | KMT2A (0.57) | MEN1KMT2AFAAHSLC6A9LMNA | |
| SCHEMBL18170175 | 0.75 | SLC6A9 (0.56) | MEN1KMT2AFAAHSLC6A9LMNA | |
| SCHEMBL18482166 | 0.74 | MEN1 (0.52) | MEN1KMT2AFAAHHDAC6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787446-B2 | Therapeutic compounds and methods of use thereof | GENENTECH, INC. (US) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787446-B2 | Therapeutic compounds and methods of use thereof | AVPR1B, C3AR1, RHEB | MEN1 463/4885KMT2A 1302/4885FAAH 3705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.