Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.66 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.66 |
| ▸ | MMP2 | P08253 | 1/20 | 0.62 |
| ▸ | MMP8 | P22894 | 1/20 | 0.62 |
| ▸ | MMP12 | P39900 | 1/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.53 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.53 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.53 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.53 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.53 |
| ▸ | GCGR | P47871 | 1/20 | 0.53 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.53 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.53 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.53 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576509 | 0.90 | ADAMTS5 (0.62) | ADAMTS5ADAMTS4MMP2MMP8MMP12 | |
| SCHEMBL2246985 | 0.89 | ADAMTS5 (0.59) | ADAMTS5ADAMTS4MMP2MMP8MMP12 | |
| SCHEMBL3586210 | 0.88 | ADAMTS5 (0.58) | ADAMTS5ADAMTS4MMP2MMP8MMP12 | |
| SCHEMBL2245328 | 0.87 | MMP12 (0.70) | ADAMTS5ADAMTS4MMP2MMP8MMP12 | |
| SCHEMBL4648193 | 0.87 | ADAMTS5 (0.59) | ADAMTS5ADAMTS4MMP2MMP8MMP12 | |
| SCHEMBL2245585 | 0.87 | ADAMTS5 (0.56) | ADAMTS5ADAMTS4MMP2MMP8MMP12 | |
| SCHEMBL2251666 | 0.86 | NPC1 (0.67) | ADAMTS5ADAMTS4MMP2MMP8MMP12 | |
| SCHEMBL2248385 | 0.86 | ADAMTS5 (0.56) | ADAMTS5ADAMTS4MMP2MMP8MMP12 | |
| SCHEMBL2247041 | 0.86 | ADAMTS5 (0.56) | ADAMTS5ADAMTS4MMP2MMP8MMP12 | |
| SCHEMBL3579414 | 0.85 | ADAMTS5 (0.57) | ADAMTS5ADAMTS4MMP2MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | claimed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | claimed |
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2010-01-14 | — | — | US | disclosed |
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | ADAMTS5, ADAMTS1, ADAMTS7 | ADAMTS5 1/4885ADAMTS4 5/4885MMP2 49/4885 |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | ADAMTS5 1/4885ADAMTS4 5/4885MMP2 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.