Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.49 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 9/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | AKT2 | P31751 | 2/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24591018 | 0.85 | MET (0.50) | METCCNKCDK12NPC1KDR | |
| SCHEMBL21167476 | 0.83 | WNT3A (0.40) | METNPC1KDRKCNH2HRH3 | |
| SCHEMBL21167707 | 0.81 | MET (0.48) | METKDRSYK | |
| SCHEMBL24591075 | 0.81 | SYK (0.40) | METNPC1KDRSYKFLT1 | |
| SCHEMBL22475774 | 0.80 | NPC1 (0.39) | NPC1KDRSYKFLT1 | |
| SCHEMBL21167803 | 0.80 | MET (0.45) | METNPC1KDRSYKFLT1 | |
| SCHEMBL24591141 | 0.78 | MET (0.54) | MET | |
| SCHEMBL24591122 | 0.78 | MET (0.44) | MET | |
| SCHEMBL12544699 | 0.76 | MET (0.45) | METNPC1KDRSYK | |
| SCHEMBL23127852 | 0.76 | MET (0.44) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |