Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | DHFR | P00374 | 3/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.52 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | FPGS | Q05932 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | GPR34 | Q9UPC5 | 3/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2251677 | 0.94 | GPR132 (0.55) | MRGPRX4DHFRHPGDSFFAR1GPR132 | |
| SCHEMBL2250715 | 0.93 | MRGPRX4 (0.51) | MRGPRX4NR1H4DHFRFFAR1GPR132 | |
| SCHEMBL2247421 | 0.91 | PARP15 (0.56) | MRGPRX4NR1H4DHFRHPGDSFFAR1 | |
| SCHEMBL2246956 | 0.91 | GRM5 (0.57) | MRGPRX4DHFRCA2CA1GPR34 | |
| SCHEMBL2245262 | 0.90 | MRGPRX4 (0.53) | MRGPRX4DHFRGPR132CA2CA1 | |
| SCHEMBL2248592 | 0.90 | DHFR (0.54) | MRGPRX4DHFRGPR132CA2CA1 | |
| SCHEMBL2247647 | 0.88 | MMP12 (0.62) | NR1H4DHFRHPGDSFFAR1AKR1B1 | |
| SCHEMBL2252396 | 0.85 | CA2 (0.57) | MRGPRX4HPGDSCA2CA1F2 | |
| SCHEMBL2243990 | 0.85 | DHFR (0.50) | MRGPRX4DHFRGPR132CA2CA1 | |
| SCHEMBL2251027 | 0.84 | CA2 (0.51) | DHFRFFAR1FFAR4GPR132CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |