Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.56 |
| ▸ | DHFR | P00374 | 3/20 | 0.54 |
| ▸ | HPGDS | O60760 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247647 | 0.90 | MMP12 (0.62) | MMP12PTPN1DHFRHPGDSFFAR1 | |
| SCHEMBL2251669 | 0.90 | MMP12 (0.61) | MMP12PTPN1DHFRHPGDSMAPT | |
| SCHEMBL2248592 | 0.88 | DHFR (0.54) | PTPN1DHFRNPC1MAPTCTSL | |
| SCHEMBL3584792 | 0.87 | FOLH1 (0.54) | MMP12DHFRCTSLCTSBCTSS | |
| SCHEMBL2249553 | 0.86 | MMP12 (0.67) | MMP12PTPN1HPGDSCTSLCTSB | |
| SCHEMBL2247420 | 0.85 | MMP12 (0.56) | MMP12PTPN1DHFRHPGDSNPC1 | |
| SCHEMBL2246953 | 0.85 | GRM5 (0.57) | MMP12PTPN1DHFRHPGDSMMP13 | |
| SCHEMBL2245261 | 0.85 | MMP12 (0.56) | MMP12PTPN1DHFRHPGDSNPC1 | |
| SCHEMBL2243988 | 0.83 | MMP12 (0.53) | MMP12PTPN1DHFRHPGDSMAPT | |
| SCHEMBL2250713 | 0.83 | MMP12 (0.54) | MMP12DHFRHPGDSNPC1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |