Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.45 |
| ▸ | MMP12 | P39900 | 2/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP10 | P09238 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | MMEL1 | Q495T6 | 4/20 | 0.36 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 7/20 | 0.36 |
| ▸ | ACE | P12821 | 5/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245203 | 0.94 | MMP2 (0.38) | MMP2MMP8MMP12ADAMTS5MMP3 | |
| SCHEMBL2254236 | 0.92 | MMP2 (0.47) | MMP2MMP8MMP12ADAMTS5MMP3 | |
| SCHEMBL2242489 | 0.92 | MMP2 (0.46) | MMP2MMP8MMP12ADAMTS5CETP | |
| SCHEMBL2248057 | 0.92 | MMP2 (0.43) | MMP2MMP8MMP12ADAMTS5MMP3 | |
| SCHEMBL2249892 | 0.91 | MMP2 (0.49) | MMP2MMP8MMP12ADAMTS5MMP9 | |
| SCHEMBL2248771 | 0.91 | MMP2 (0.44) | MMP2MMP8MMP12ADAMTS5CETP | |
| SCHEMBL2247912 | 0.88 | MMP2 (0.43) | MMP2MMP8MMP12ADAMTS5CETP | |
| SCHEMBL2247715 | 0.87 | CYP3A4 (0.39) | MMP2MMP8MMP12ADAMTS5 | |
| SCHEMBL2247595 | 0.87 | MMP2 (0.43) | MMP2MMP8MMP12ADAMTS5CETP | |
| SCHEMBL2247342 | 0.86 | MMP2 (0.41) | MMP2MMP8MMP12ADAMTS5MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | claimed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | claimed |
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2010-01-14 | — | — | US | disclosed |
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | ADAMTS5, ADAMTS1, ADAMTS7 | MMP2 49/4885MMP8 70/4885MMP12 54/4885 |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | MMP2 49/4885MMP8 70/4885MMP12 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.