Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23463158 | 0.81 | ALDH1A1 (0.35) | ALDH1A1POLBMAPTHTTGRIN2D | |
| SCHEMBL21468611 | 0.78 | ALDH1A1 (0.33) | ALDH1A1POLBMAPT | |
| SCHEMBL10172752 | 0.77 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10TSHRRAB9A | |
| SCHEMBL882160 | 0.77 | ALDH1A1 (0.40) | ALDH1A1POLBMAPTLMNAHSD17B10 | |
| SCHEMBL7934757 | 0.77 | ALDH1A1 (0.40) | ALDH1A1POLBMAPTLMNAHSD17B10 | |
| SCHEMBL15933348 | 0.76 | ALDH1A1 (0.37) | ALDH1A1POLBMAPTLMNAHSD17B10 | |
| SCHEMBL10955234 | 0.75 | ALDH1A1 (0.42) | ALDH1A1POLBMAPTLMNAHSD17B10 | |
| SCHEMBL13346809 | 0.74 | ALDH1A1 (0.41) | ALDH1A1POLBMAPTHTTGRIN2D | |
| SCHEMBL13346798 | 0.73 | THRB (0.40) | ALDH1A1POLBMAPTHTTCYP3A4 | |
| SCHEMBL24502636 | 0.73 | ALDH1A1 (0.38) | ALDH1A1POLBMAPTHTTGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200306243-A1 | COMPOUNDS AND CONJUGATES THEREOF | MEDIMMUNE LIMITED (GB) | 2020-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200306243-A1 | COMPOUNDS AND CONJUGATES THEREOF | TOP2A, TOP1, TOP2B | ALDH1A1 1742/4885POLB 169/4885MAPT 1295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.