Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2242699 | 0.83 | MAOB (0.50) | CA2TSHRMAPK1ALDH1A1NR3C1 | |
| SCHEMBL16641175 | 0.78 | CA2 (0.54) | CA2CA12CA1CA7CA9 | |
| SCHEMBL25244389 | 0.78 | ALDH1A1 (0.42) | TSHRARCYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL31494287 | 0.78 | ALDH1A1 (0.42) | TSHRARCYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL18315294 | 0.76 | CA2 (0.52) | CA2CA12CA1CA7CA9 | |
| SCHEMBL509522 | 0.72 | AR (0.66) | CA2CA12CA1CA7CA9 | |
| SCHEMBL18245103 | 0.72 | CA2 (0.48) | CA2CA12CA1CA7CA9 | |
| SCHEMBL8864683 | 0.72 | CA2 (0.48) | CA2CA12CA1CA7CA9 | |
| SCHEMBL56335 | 0.72 | CA2 (0.48) | CA2CA12CA1CA7CA9 | |
| SCHEMBL10423499 | 0.72 | CA2 (0.48) | CA2CA12CA1CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265620-B1 | SPIRO DERIVATIVES OF PARTHENIN AS NOVEL ANTICANCER AGENTS | COUNCIL SCIENT IND RES (IN) | 2014-06-18 | — | — | EP | disclosed |
| US-8609858-B2 | Spiro derivatives of parthenin as novel anticancer agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-12-17 | — | — | US | disclosed |
| US-20110201661-A1 | Spiro Derivatives of Parthenin as Novel Anticancer Agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-08-18 | — | — | US | disclosed |
| EP-2265620-A1 | SPIRO DERIVATIVES OF PARTHENIN AS NOVEL ANTICANCER AGENTS | Council Of Scientific & Industrial Research (IN) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009110007-A1 | SPIRO DERIVATIVES OF PARTHENIN AS NOVEL ANTICANCER AGENTS | COUNCIL QF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2009-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201661-A1 | Spiro Derivatives of Parthenin as Novel Anticancer Agents | CDK10, NEK10, AKR1B10 | CA2 3317/4885CA12 4225/4885CA1 4049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.