Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.51 |
| ▸ | FOXO1 | Q12778 | 2/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 3/20 | 0.49 |
| ▸ | MMP9 | P14780 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22489011 | 0.91 | MMP2 (0.59) | NPC1RAB9AKDM4EPKMSMN1; SMN2 | |
| SCHEMBL22488979 | 0.90 | NPC1 (0.61) | NPC1RAB9AKDM4EHPSEMEN1 | |
| SCHEMBL22488981 | 0.89 | NPC1 (0.64) | NPC1RAB9AKDM4ETP53PKM | |
| SCHEMBL22488747 | 0.89 | ADORA2A (0.60) | NPC1RAB9AKDM4ETP53SMN1; SMN2 | |
| SCHEMBL22488976 | 0.89 | NPC1 (0.60) | NPC1RAB9AKDM4EPKMHPSE | |
| SCHEMBL22489156 | 0.87 | NPC1 (0.47) | NPC1RAB9AKDM4ETP53PKM | |
| SCHEMBL22489164 | 0.86 | COMT (0.64) | NPC1RAB9AKDM4ETP53PKM | |
| SCHEMBL24513213 | 0.86 | FOXO1 (0.52) | NPC1RAB9AKDM4EPKMHPSE | |
| SCHEMBL22489134 | 0.86 | FOXO1 (0.58) | NPC1RAB9AKDM4EHPSEMEN1 | |
| SCHEMBL24513588 | 0.84 | MAPT (0.63) | NPC1RAB9AKDM4ETP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220185797-A1 | SELECTIVE FOXO INHIBITORS FOR TREATMENT OF DIABETES AND OTHER DISORDERS RELATED TO IMPAIRED PANCREATIC FUNCTION | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2022-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185797-A1 | SELECTIVE FOXO INHIBITORS FOR TREATMENT OF DIABETES AND OTHER DISORDERS RELATED TO IMPAIRED PANCREATIC FUNCTION | FOXO1, FOXO3, FOXK1 | NPC1 3743/4885RAB9A 1948/4885KDM4E 320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.