SCHEMBL22490880

SCHEMBL22490880

COc1c(Cl)c(OCc2ccccc2)c(Cl)c(C)c1C(=O)OC[C@H]1O[C@H](O)[C@H](OC)[C@@H](O)[C@@H]1O

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TNF P01375 1/20 0.37
PDE4D Q08499 1/20 0.35
KCNA3 P22001 1/20 0.34
LGALS8 O00214 1/20 0.34
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33
USP2 O75604 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TACR2 P21452 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23488516 0.89 LGALS8 (0.40) PDE4DKCNA3LGALS8
SCHEMBL23488579 0.89 LGALS8 (0.40) PDE4DKCNA3LGALS8
SCHEMBL23488282 0.89 LGALS8 (0.40) PDE4DKCNA3LGALS8
SCHEMBL23488171 0.80 LGALS8 (0.47) LGALS8
SCHEMBL23488142 0.80 LGALS8 (0.47) LGALS8
SCHEMBL23488694 0.80 LGALS8 (0.47) LGALS8
SCHEMBL22490881 0.80 SLC6A2 (0.36) PDE4DKCNA3LMNAHPGD
SCHEMBL23488522 0.78 LGALS8 (0.47) KCNA3LGALS8
SCHEMBL23488170 0.78 LGALS8 (0.47) KCNA3LGALS8
SCHEMBL23488518 0.78 LGALS8 (0.47) KCNA3LGALS8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-06-10 US disclosed
EP-3717463-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN Sanofi (FR) 2020-10-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 TNF 4667/4885PDE4D 1147/4885KCNA3 4345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.