SCHEMBL22490883

SCHEMBL22490883

O=C(CCOC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O)c1ccc(OCc2ccccc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
EGFR P00533 7/20 0.49
PARP10 Q53GL7 1/20 0.47
NR4A1 P22736 1/20 0.46
NR4A2 P43354 1/20 0.46
NR4A3 Q92570 1/20 0.46
MAOB P27338 1/20 0.44
SRD5A2 P31213 1/20 0.43
ALDH1A1 P00352 1/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
HTT P42858 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
PLA2G4B P0C869 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
FFAR1 O14842 1/20 0.41
FFAR4 Q5NUL3 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22490915 0.89 PARP10 (0.49) EGFRPARP10NR4A1NR4A2NR4A3
SCHEMBL22490875 0.89 PARP10 (0.49) EGFRPARP10NR4A1NR4A2NR4A3
SCHEMBL22490933 0.89 PARP10 (0.49) EGFRPARP10NR4A1NR4A2NR4A3
SCHEMBL22490902 0.82 CHRNB2 (0.52) EGFRPARP10NR4A1NR4A2NR4A3
SCHEMBL11290489 0.79 EGFR (0.66) EGFRPARP10NR4A1NR4A2NR4A3
SCHEMBL18425232 0.76 SLC6A2 (0.51)
SCHEMBL7599764 0.76 SLC6A2 (0.58)
SCHEMBL7599757 0.76 SLC6A2 (0.58)
SCHEMBL22490866 0.75 HDAC3 (0.52) PARP10NR4A1NR4A2NR4A3MAPT
SCHEMBL29546413 0.75 SLC6A2 (0.49) HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-06-10 US disclosed
EP-3717463-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN Sanofi (FR) 2020-10-07 EP disclosed
CN-111433193-A Novel conjugates of agents and moieties capable of binding to glucose sensing proteins 赛诺菲 2020-07-17 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 EGFR 1469/4885PARP10 1135/4885NR4A1 4102/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.