SCHEMBL22490898

SCHEMBL22490898

COc1c(Cl)c(OCc2ccccc2)c(Cl)c(C)c1C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PDE4D Q08499 1/20 0.45
KCNA3 P22001 1/20 0.44
PTPN1 P18031 1/20 0.44
HPGD P15428 2/20 0.44
LMNA P02545 1/20 0.44
MCL1 Q07820 1/20 0.43
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
HSD17B10 Q99714 1/20 0.42
RXRA P19793 1/20 0.42
POLB P06746 1/20 0.42
GLRA1 P23415 1/20 0.41
MRGPRX4 Q96LA9 1/20 0.41
PTGER1 P34995 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31643912 0.81 KCNA3 (0.49) KCNA3PTPN1HPGDLMNARXRA
SCHEMBL8043037 0.78 PTPN1 (0.44) PDE4DPTPN1HPGDLMNAMCL1
SCHEMBL26608325 0.76 KCNA3 (0.46) PDE4DKCNA3PTPN1HPGDLMNA
SCHEMBL13233013 0.76 PTPN1 (0.52) PTPN1HPGDLMNAALDH1A1RXRA
SCHEMBL9287344 0.76 PTPN1 (0.40) PDE4DKCNA3PTPN1HPGDLMNA
SCHEMBL22490852 0.76 MCL1 (0.48) PDE4DHPGDLMNAMCL1KDM4E
SCHEMBL1591366 0.76 KCNA3 (0.55) KCNA3HPGDLMNAKDM4EALDH1A1
SCHEMBL23488282 0.75 LGALS8 (0.40) PDE4DKCNA3
SCHEMBL23488579 0.75 LGALS8 (0.40) PDE4DKCNA3
SCHEMBL23488516 0.75 LGALS8 (0.40) PDE4DKCNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-06-10 US disclosed
EP-3717463-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN Sanofi (FR) 2020-10-07 EP disclosed
CN-111433193-A Novel conjugates of agents and moieties capable of binding to glucose sensing proteins 赛诺菲 2020-07-17 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 PDE4D 1147/4885KCNA3 4345/4885PTPN1 2662/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.