Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.38 |
| ▸ | ACE | P12821 | 3/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 7/20 | 0.37 |
| ▸ | CPB1 | P15086 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22491316 | 0.78 | ACE (0.43) | ACE2ACECPB2CAPN1FNTA | |
| SCHEMBL13046895 | 0.77 | ACE2 (0.41) | ACE2ACECPB2CPB1CHRM1 | |
| SCHEMBL22491303 | 0.77 | ACE2 (0.47) | ACE2ACEFNTAFNTB | |
| SCHEMBL22491297 | 0.77 | ACE2 (0.46) | ACE2ACEFNTAFNTB | |
| SCHEMBL20839555 | 0.76 | ACE2 (0.40) | ACE2ACECHRM1CHRM3HTR2A | |
| SCHEMBL7229610 | 0.74 | CD274 (0.39) | ACE2ACEFNTAFNTB | |
| SCHEMBL5869631 | 0.74 | ACE2 (0.61) | ACE2ACE | |
| SCHEMBL4686868 | 0.74 | ITGB3 (0.43) | ACE2ACE | |
| SCHEMBL22491318 | 0.73 | ACE2 (0.35) | ACE2ACECPB2CPB1CHRM1 | |
| SCHEMBL634586 | 0.73 | ITGA4 (0.45) | ACE2ACECAPN1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3717077-A1 | METHODS FOR MODULATING PIGMENTATION BY ANGIOTENSIN-CONVERTING ENZYME 2 MODULATION | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (DE) | 2020-10-07 | — | — | EP | disclosed |