Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16530180 | 0.90 | MAPT (0.44) | MAPTGAAALDH1A1CHRM1L3MBTL1 | |
| SCHEMBL20565214 | 0.85 | POLB (0.38) | MAPTGAAALDH1A1L3MBTL1THRB | |
| SCHEMBL22655482 | 0.81 | GPR119 (0.48) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL19074507 | 0.81 | GPR119 (0.48) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL28981659 | 0.81 | MEN1 (0.35) | MAPTGAAALDH1A1L3MBTL1MEN1 | |
| SCHEMBL14431954 | 0.80 | L3MBTL1 (0.41) | MAPTGAAALDH1A1CHRM1L3MBTL1 | |
| SCHEMBL29429485 | 0.80 | LMNA (0.47) | MAPTGAAALDH1A1CHRM1L3MBTL1 | |
| SCHEMBL30120842 | 0.79 | GAA (0.38) | MAPTGAAALDH1A1CHRM1L3MBTL1 | |
| SCHEMBL26694770 | 0.78 | DPP4 (0.36) | ALDH1A1MEN1KMT2A | |
| SCHEMBL29806439 | 0.77 | GAA (0.49) | MAPTGAAALDH1A1CHRM1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313313-A1 | ARYL HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D.E. Shaw Research, LLC (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022212296-A1 | ARYL HETEROCYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D.E. SHAW RESEARCH, LLC (US) | 2022-10-06 | — | — | WO | disclosed |
| EP-3717486-A1 | PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST THE RESPIRATORY SYNCYTIAL VIRUS (RSV) | Janssen Sciences Ireland Unlimited Company (IE) | 2020-10-07 | — | — | EP | disclosed |