Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30543794 | 0.88 | LMNA (0.48) | LMNAPOLBSMN1; SMN2GAACHRM1 | |
| SCHEMBL2361594 | 0.81 | LMNA (0.49) | LMNAPOLBSMN1; SMN2GAACHRM1 | |
| SCHEMBL29356156 | 0.80 | LMNA (0.46) | LMNAPOLBSMN1; SMN2GAACHRM1 | |
| SCHEMBL22491827 | 0.80 | MAPT (0.42) | SMN1; SMN2GAACHRM1THRBATM | |
| SCHEMBL19074507 | 0.80 | GPR119 (0.48) | L3MBTL1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL22655482 | 0.80 | GPR119 (0.48) | L3MBTL1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL29850834 | 0.79 | LMNA (0.56) | LMNAPOLBSMN1; SMN2GAACHRM1 | |
| SCHEMBL12468859 | 0.78 | SMN1; SMN2 (0.47) | LMNAPOLBSMN1; SMN2GAACHRM1 | |
| SCHEMBL12468609 | 0.78 | SMN1; SMN2 (0.47) | LMNAPOLBSMN1; SMN2GAACHRM1 | |
| SCHEMBL12142025 | 0.78 | GAA (0.53) | POLBSMN1; SMN2GAACHRM1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3717486-B1 | PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST THE RESPIRATORY SYNCYTIAL VIRUS (RSV) | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2022-03-23 | — | — | EP | disclosed |