Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.37 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5242504 | 1.00 | HTT (0.46) | HTTKDM4EKMT2AL3MBTL1NAPRT | |
| SCHEMBL9683262 | 0.82 | ALDH1A1 (0.43) | HTTKDM4EKMT2AALDH1A1HPGD | |
| SCHEMBL9683260 | 0.82 | ALDH1A1 (0.43) | HTTKDM4EKMT2AALDH1A1HPGD | |
| SCHEMBL4783822 | 0.81 | MKNK1 (0.38) | HTTKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL1582996 | 0.80 | ALDH1A1 (0.46) | HTTKDM4EKMT2ACYP1A2CYP3A4 | |
| SCHEMBL27770173 | 0.78 | LMNA (0.44) | HTTKDM4EL3MBTL1LMNAALDH1A1 | |
| SCHEMBL7020743 | 0.78 | MAPT (0.44) | KDM4EL3MBTL1CYP1A2CYP2C19LMNA | |
| SCHEMBL23649485 | 0.77 | UHRF1 (0.38) | HTTKDM4EALDH1A1 | |
| SCHEMBL4734212 | 0.77 | CYP2E1 (0.34) | HTTKDM4EKMT2AL3MBTL1CYP1A2 | |
| SCHEMBL9111206 | 0.75 | CYP11B1 (0.41) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3717450-A1 | COMPOUNDS AND METHODS FOR HEMATOPOIETIC REGENERATION | The Regents of the University of California (US) | 2020-10-07 | — | — | EP | disclosed |