SCHEMBL22492993

SCHEMBL22492993

N=C(n1cc(-c2ccccc2)cn1)n1cc(-c2ccccc2)cn1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.46
WDR5 P61964 1/20 0.36
ALDH1A1 P00352 1/20 0.36
F2 P00734 1/20 0.36
PLAU P00749 1/20 0.36
ELANE P08246 1/20 0.36
ATM Q13315 1/20 0.35
KDR P35968 2/20 0.35
NPC1 O15118 1/20 0.34
NFKB1 P19838 1/20 0.34
RAB9A P51151 1/20 0.34
NFKB2 Q00653 1/20 0.34
RELA Q04206 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
MAP4K4 O95819 1/20 0.34
PAK4 O96013 1/20 0.34
CSF1R P07333 1/20 0.34
RET P07949 1/20 0.34
GRK5 P34947 1/20 0.34
MAPK8 P45983 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5813750 0.85 NOS1 (0.52) L3MBTL1WDR5F2ATMMAP4K4
SCHEMBL2636867 0.80 L3MBTL1 (0.46) L3MBTL1ALDH1A1F2PLAUELANE
SCHEMBL25445548 0.70 ROCK2 (0.56)
SCHEMBL244970 0.68 KDR (0.56) L3MBTL1KDRACVR1DYRK1AEPHB4
SCHEMBL3753666 0.68 L3MBTL1 (0.50) L3MBTL1WDR5ALDH1A1ATMKDR
SCHEMBL28816219 0.68 L3MBTL1 (0.50) L3MBTL1ALDH1A1ATMKDRNPC1
SCHEMBL23845574 0.68 L3MBTL1 (0.50) L3MBTL1WDR5ALDH1A1ATMKDR
SCHEMBL27684583 0.68 L3MBTL1 (0.50) L3MBTL1ALDH1A1ATMKDRNPC1
Ammonia Solution, Strong SCHEMBL18398465 0.67 KDR (0.55) L3MBTL1KDRACVR1DYRK1AEPHB4
SCHEMBL20774126 0.67 KDR (0.55) L3MBTL1KDRACVR1DYRK1AEPHB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11788080-B2 Modified cleavases, uses thereof and related kits Encodia, Inc. (US) 2023-10-17 US disclosed
US-11788080-B2 Modified cleavases, uses thereof and related kits Encodia, Inc. (US) 2023-10-17 US disclosed
US-20230257727-A1 MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2023-08-17 US disclosed
US-20230257727-A1 MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2023-08-17 US disclosed
US-20230021091-A1 MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2023-01-19 US disclosed
WO-2021194908-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2021-09-30 WO disclosed
US-20210214701-A1 MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2021-07-15 US disclosed
WO-2020223133-A1 METHODS AND REAGENTS FOR CLEAVAGE OF THE N-TERMINAL AMINO ACID FROM A POLYPEPTIDE Encodia, Inc. (US) 2020-11-05 WO disclosed
WO-2020198264-A1 MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2020-10-01 WO disclosed