Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.45 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.44 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407653 | 0.84 | DGAT1 (0.49) | MAPTALDH1A1GAASMN1; SMN2DGAT1 | |
| SCHEMBL407225 | 0.83 | DGAT1 (0.48) | MAPTALDH1A1SMN1; SMN2DGAT1POLB | |
| SCHEMBL442691 | 0.83 | DGAT1 (0.61) | ALDH1A1GAASMN1; SMN2DGAT1MAPK1 | |
| SCHEMBL408707 | 0.82 | PDE4B (0.50) | ALDH1A1DGAT1MAPK1NPSR1 | |
| SCHEMBL407661 | 0.81 | DGAT1 (0.47) | MAPTALDH1A1GAADGAT1MAPK1 | |
| SCHEMBL22493020 | 0.81 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2DGAT1MAPK1 | |
| SCHEMBL408172 | 0.79 | NPSR1 (0.60) | MAPTALDH1A1SMN1; SMN2DGAT1POLB | |
| SCHEMBL408667 | 0.77 | DGAT1 (0.43) | ALDH1A1GAADGAT1MAPK1LMNA | |
| SCHEMBL20304409 | 0.76 | TDP1 (0.46) | SMN1; SMN2DGAT1MAPK1NPC1NFKB1 | |
| SCHEMBL407666 | 0.76 | DGAT1 (0.62) | MAPTALDH1A1GAASMN1; SMN2DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11655203-B2 | Nitration | ETH ZURICH (CH) | 2023-05-23 | — | — | US | disclosed |
| US-20220009875-A1 | NITRATION | ETH ZURICH (CH) | 2022-01-13 | — | — | US | disclosed |
| CN-113302186-A | Nitration | 瑞士苏黎世联邦理工学院 | 2021-08-24 | — | — | CN | disclosed |
| EP-3717464-B1 | NITRATION | ETH ZUERICH (CH) | 2021-06-16 | — | — | EP | disclosed |
| EP-3717464-A1 | NITRATION | ETH Zurich (CH) | 2020-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220009875-A1 | NITRATION | NOS1, NOS2, NOS3 | MAPT 3137/4885ALDH1A1 2335/4885GAA 4180/4885 |
| US-11655203-B2 | Nitration | NOS1, NOS2, NOS3 | MAPT 3137/4885ALDH1A1 2335/4885GAA 4180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.