SCHEMBL22493136

SCHEMBL22493136

NC(=O)C1C(=O)N(c2ccc(F)c(F)c2F)CCC1c1cccc(C(F)(F)F)c1

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
RPS6KB1 P23443 1/20 0.41
AKT1 P31749 1/20 0.41
FPR1 P21462 14/20 0.40
FPR2 P25090 14/20 0.40
GUSB P08236 1/20 0.36
HTR2A P28223 1/20 0.36
HTR2C P28335 1/20 0.36
HTR2B P41595 1/20 0.36
GPR52 Q9Y2T5 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22493132 0.93 RPS6KB1 (0.39) RPS6KB1AKT1FPR1FPR2HTR2A
SCHEMBL22493137 0.93 RPS6KB1 (0.39) RPS6KB1AKT1FPR1FPR2HTR2A
SCHEMBL25313489 0.90 RPS6KB1 (0.38) RPS6KB1AKT1FPR1FPR2GUSB
SCHEMBL22493135 0.87 GRM2 (0.38) RPS6KB1AKT1FPR1FPR2HTR2A
SCHEMBL25317840 0.83 HTR2B (0.38) RPS6KB1AKT1GUSBHTR2AHTR2C
SCHEMBL22493138 0.83 FPR1 (0.38) RPS6KB1FPR1FPR2
SCHEMBL22493139 0.81 FPR2 (0.39) FPR1FPR2
SCHEMBL22493133 0.81 FPR2 (0.39) FPR1FPR2
SCHEMBL20521329 0.78 HTR2C (0.41) RPS6KB1AKT1GUSBHTR2AHTR2C
SCHEMBL25319499 0.78 ALDH1A1 (0.40) RPS6KB1AKT1GUSBHTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3164386-B1 PIPERIDINONE HERBICIDES FMC CORP (US) 2020-10-07 EP claimed