Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22518781 | 1.00 | EHMT2 (0.50) | EHMT2ALDH1A1TSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL34469032 | 1.00 | EHMT2 (0.50) | EHMT2ALDH1A1TSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL34469179 | 0.80 | CMA1 (0.47) | ALDH1A1MEN1KMT2ACMA1 | |
| SCHEMBL22645696 | 0.80 | CMA1 (0.47) | ALDH1A1MEN1KMT2ACMA1 | |
| SCHEMBL22645709 | 0.80 | CMA1 (0.47) | ALDH1A1MEN1KMT2ACMA1 | |
| SCHEMBL20833763 | 0.80 | CMA1 (0.47) | ALDH1A1MEN1KMT2ACMA1 | |
| SCHEMBL22661096 | 0.80 | CMA1 (0.47) | ALDH1A1MEN1KMT2ACMA1 | |
| SCHEMBL2079921 | 0.76 | TSHR (0.49) | EHMT2ALDH1A1TSHRSMN1; SMN2CYP3A4 | |
| SCHEMBL4998470 | 0.72 | SMN1; SMN2 (0.43) | ALDH1A1TSHRSMN1; SMN2EP300USP2 | |
| SCHEMBL23706931 | 0.71 | ALDH1A1 (0.36) | EHMT2ALDH1A1TSHRSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078153-B2 | 2-difluoro substituted 4-aminocyclopentanecarboxylic acids as inhibitors of gamma-aminobutyric acid aminotransferase and human ornithine aminotransferase | NORTHWESTERN UNIVERSITY (US) | 2021-08-03 | — | — | US | disclosed |
| US-20200317606-A1 | 2-DIFLUORO SUBSTITUTED 4-AMINOCYCLOPENTANECARBOXYLIC ACIDS AS INHIBITORS OF GAMMA-AMINOBUTYRIC ACID AMINOTRANSFERASE AND HUMAN ORNITHINE AMINOTRANSFERASE | NORTHWESTERN UNIVERSITY (US) | 2020-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078153-B2 | 2-difluoro substituted 4-aminocyclopentanecarboxylic acids as inhibitors of gamma-aminobutyric acid aminotransferase and human ornithine aminotransferase | OAT, OTC, SLC6A13 | EHMT2 3930/4885ALDH1A1 169/4885TSHR 2188/4885 |
| US-20200317606-A1 | 2-DIFLUORO SUBSTITUTED 4-AMINOCYCLOPENTANECARBOXYLIC ACIDS AS INHIBITORS OF GAMMA-AMINOBUTYRIC ACID AMINOTRANSFERASE AND HUMAN ORNITHINE AMINOTRANSFERASE | OAT, OTC, SLC6A13 | EHMT2 3930/4885ALDH1A1 169/4885TSHR 2188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.