SCHEMBL2250811

SCHEMBL2250811

CCOc1c2cc[c]cc2cc2ccccc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.36
SLC2A1 P11166 1/20 0.36
GPR84 Q9NQS5 1/20 0.35
NR1I2 O75469 1/20 0.35
BTK Q06187 1/20 0.34
HTR2A P28223 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
TUBB4A P04350 1/20 0.33
TUBB P07437 1/20 0.33
TUBA3C P0DPH7 1/20 0.33
TUBA1B P68363 1/20 0.33
TUBA4A P68366 1/20 0.33
TUBB4B P68371 1/20 0.33
TUBB3 Q13509 1/20 0.33
TUBB2A Q13885 1/20 0.33
TUBB8 Q3ZCM7 1/20 0.33
TUBA3E Q6PEY2 1/20 0.33
TUBA1A Q71U36 1/20 0.33
TUBA1C Q9BQE3 1/20 0.33
TUBB6 Q9BUF5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2254017 0.91 SLC2A1 (0.36) ALOX5SLC2A1GPR84NR1I2BTK
SCHEMBL2253032 0.87 SLC2A1 (0.40) SLC2A1L3MBTL1TLR8LMNAABCB11
SCHEMBL644629 0.85 GPR84 (0.44) ALOX5SLC2A1GPR84NR1I2BTK
SCHEMBL29694174 0.85 GPR84 (0.44) ALOX5SLC2A1GPR84NR1I2BTK
SCHEMBL2254051 0.82 KDM4E (0.47) ALOX5GPR84TUBB4ATUBBTUBA3C
SCHEMBL5746505 0.79 HTR2A (0.44) ALOX5NR1I2HTR2AL3MBTL1KDM4E
Boric Acid SCHEMBL28924899 0.78 SLC2A1 (0.43) ALOX5SLC2A1GPR84NR1I2BTK
SCHEMBL2255426 0.78 SLC2A1 (0.40) SLC2A1L3MBTL1TLR8LMNAABCB11
SCHEMBL2700216 0.76 CYP1A2 (0.41) ALOX5HTR2AL3MBTL1KDM4ERAB9A
SCHEMBL2255289 0.75 GPR84 (0.38) ALOX5SLC2A1GPR84NR1I2BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1916244-B1 THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME NISSAN CHEMICAL IND LTD (JP) 2013-12-04 EP disclosed
EP-1882694-B1 OLIGOMERS AND POLYMERS OF THIOPHENE COMPOUNDS HAVING PHOSPHORIC ESTER AND PROCESS FOR PRODUCING THE SAME NISSAN CHEMICAL IND LTD (JP) 2013-04-03 EP disclosed
US-8008425-B2 Thiophene compound having sulfonyl group and process for producing the same NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-08-30 US disclosed
US-20090127491-A1 THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-05-21 US disclosed
EP-1916244-A1 THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME Nissan Chemical Industries, Ltd. (JP) 2008-04-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090127491-A1 THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME TST, ABCG2, CBR3 ALOX5 2166/4885SLC2A1 308/4885GPR84 3574/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.