SCHEMBL2255289

SCHEMBL2255289

CCOc1c2[c]cccc2cc2ccccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 1/20 0.38
NR1I2 O75469 1/20 0.38
SLC2A1 P11166 1/20 0.36
BTK Q06187 1/20 0.34
L3MBTL1 Q9Y468 2/20 0.33
HTR2A P28223 1/20 0.33
ALOX5 P09917 1/20 0.33
TUBB4A P04350 1/20 0.33
TUBB P07437 1/20 0.33
TUBA3C P0DPH7 1/20 0.33
TUBA1B P68363 1/20 0.33
TUBA4A P68366 1/20 0.33
TUBB4B P68371 1/20 0.33
TUBB3 Q13509 1/20 0.33
TUBB2A Q13885 1/20 0.33
TUBB8 Q3ZCM7 1/20 0.33
TUBA3E Q6PEY2 1/20 0.33
TUBA1A Q71U36 1/20 0.33
TUBA1C Q9BQE3 1/20 0.33
TUBB6 Q9BUF5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2252754 0.87 SLC2A1 (0.40) GPR84SLC2A1L3MBTL1TLR8LMNA
SCHEMBL5028533 0.82 ERN1 (0.43) GPR84ALOX5TUBB4ATUBBTUBA3C
SCHEMBL2252135 0.81 SLC2A1 (0.36) GPR84NR1I2SLC2A1BTKALOX5
SCHEMBL644629 0.81 GPR84 (0.44) GPR84NR1I2SLC2A1BTKL3MBTL1
SCHEMBL29694174 0.81 GPR84 (0.44) GPR84NR1I2SLC2A1BTKL3MBTL1
SCHEMBL1217965 0.76 HTR2A (0.44) NR1I2L3MBTL1HTR2AKDM4EHPGD
SCHEMBL2254017 0.75 SLC2A1 (0.36) GPR84NR1I2SLC2A1BTKL3MBTL1
SCHEMBL2250811 0.75 ALOX5 (0.36) GPR84NR1I2SLC2A1BTKL3MBTL1
Boric Acid SCHEMBL28924899 0.75 SLC2A1 (0.43) GPR84NR1I2SLC2A1BTKL3MBTL1
SCHEMBL23089905 0.73 CYP2A6 (0.41) GPR84NR1I2SLC2A1BTKHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1916244-B1 THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME NISSAN CHEMICAL IND LTD (JP) 2013-12-04 EP disclosed
EP-1882694-B1 OLIGOMERS AND POLYMERS OF THIOPHENE COMPOUNDS HAVING PHOSPHORIC ESTER AND PROCESS FOR PRODUCING THE SAME NISSAN CHEMICAL IND LTD (JP) 2013-04-03 EP disclosed
US-8008425-B2 Thiophene compound having sulfonyl group and process for producing the same NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-08-30 US disclosed
US-20090127491-A1 THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-05-21 US disclosed
EP-1916244-A1 THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME Nissan Chemical Industries, Ltd. (JP) 2008-04-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090127491-A1 THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME TST, ABCG2, CBR3 GPR84 3574/4885NR1I2 2045/4885SLC2A1 308/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.