Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 15/20 | 0.38 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.36 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22548154 | 0.96 | HSP90AA1 (0.39) | HSP90AA1CCR2HSP90AB1PDK1CCR3 | |
| SCHEMBL22548219 | 0.96 | CCR2 (0.40) | HSP90AA1CCR2HSP90AB1PDK1BRD4 | |
| SCHEMBL22548269 | 0.91 | CCR3 (0.39) | HSP90AA1HSP90AB1PDK1CCR3HSP90B1 | |
| SCHEMBL22547832 | 0.85 | CCR3 (0.39) | HSP90AA1HSP90AB1BRD4CCR3 | |
| SCHEMBL22541300 | 0.84 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1PDK1BRD4HSP90B1 | |
| SCHEMBL22541296 | 0.83 | MEN1 (0.43) | HSP90AA1HSP90AB1PDK1BRD4HSP90B1 | |
| SCHEMBL16569200 | 0.82 | KDM4E (0.42) | HSP90AA1HSP90AB1 | |
| SCHEMBL24321350 | 0.82 | MEN1 (0.47) | HSP90AA1HSP90AB1PDK1HSP90B1TRAP1 | |
| SCHEMBL24321700 | 0.82 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL18561685 | 0.82 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1PDK1BRD4HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020207396-A1 | METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION | RANOK THERAPEUTICS (HANGZHOU) CO. LTD. (CN) | 2020-10-15 | — | — | WO | disclosed |
| WO-2020207395-A1 | METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION | RANOK THERAPEUTICS (HANGZHOU) CO., LTD. (CN) | 2020-10-15 | — | — | WO | disclosed |