Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 14/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.40 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22541290 | 0.90 | BRD4 (0.41) | HSP90AA1HSP90AB1BRD4KDM4EALDH1A1 | |
| SCHEMBL16569200 | 0.89 | KDM4E (0.42) | HSP90AA1HSP90AB1KDM4EALDH1A1TDP1 | |
| SCHEMBL24321350 | 0.89 | MEN1 (0.47) | HSP90AA1HSP90AB1PDK1HSP90B1TRAP1 | |
| SCHEMBL22548219 | 0.89 | CCR2 (0.40) | HSP90AA1HSP90AB1PDK1BRD4HSP90B1 | |
| SCHEMBL24321700 | 0.88 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1HSP90B1TRAP1KDM4E | |
| SCHEMBL18561685 | 0.88 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1PDK1BRD4HSP90B1 | |
| SCHEMBL24321184 | 0.88 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1PDK1HSP90B1TRAP1 | |
| SCHEMBL24321134 | 0.87 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1HSP90B1KDM4EALDH1A1 | |
| SCHEMBL22548269 | 0.86 | CCR3 (0.39) | HSP90AA1HSP90AB1PDK1HSP90B1TRAP1 | |
| SCHEMBL22541280 | 0.84 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1PDK1BRD4HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020207395-A1 | METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION | RANOK THERAPEUTICS (HANGZHOU) CO., LTD. (CN) | 2020-10-15 | — | — | WO | disclosed |