Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24334860 | 0.93 | BRD4 (0.40) | BRD4KDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL22541300 | 0.90 | HSP90AA1 (0.40) | BRD4KDM4EALDH1A1TDP1HSP90AA1 | |
| SCHEMBL22547832 | 0.88 | CCR3 (0.39) | BRD4KDM4EALDH1A1TDP1HSP90AA1 | |
| SCHEMBL22541229 | 0.82 | BRD4 (0.47) | BRD4HSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL29460122 | 0.80 | HSP90AA1 (0.39) | BRD4KDM4EALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL28690492 | 0.80 | HSP90AA1 (0.39) | BRD4KDM4EALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL24477130 | 0.80 | BRD4 (0.44) | BRD4KDM4EALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL24321161 | 0.79 | L3MBTL1 (0.44) | KDM4EALDH1A1TDP1L3MBTL1MAPT | |
| SCHEMBL18561685 | 0.79 | HSP90AA1 (0.40) | BRD4KDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL22548219 | 0.79 | CCR2 (0.40) | BRD4HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020207396-A1 | METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION | RANOK THERAPEUTICS (HANGZHOU) CO. LTD. (CN) | 2020-10-15 | — | — | WO | disclosed |
| WO-2020207395-A1 | METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION | RANOK THERAPEUTICS (HANGZHOU) CO., LTD. (CN) | 2020-10-15 | — | — | WO | disclosed |