Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 3/20 | 0.36 |
| ▸ | NOS1 | P29475 | 3/20 | 0.36 |
| ▸ | NOS2 | P35228 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24451719 | 0.84 | SIGMAR1 (0.42) | SIGMAR1DRD2SMN1; SMN2NOS3NOS1 | |
| SCHEMBL20884875 | 0.82 | SIGMAR1 (0.41) | SIGMAR1DRD2SMN1; SMN2NOS3NOS1 | |
| SCHEMBL22542094 | 0.81 | SIGMAR1 (0.48) | SIGMAR1DRD2DRD3SMN1; SMN2SLC6A4 | |
| SCHEMBL22542119 | 0.80 | SLC18A3 (0.48) | DRD2DRD4DRD3SLC6A4 | |
| SCHEMBL22542112 | 0.77 | DRD2 (0.43) | DRD2DRD4DRD3SLC6A4 | |
| SCHEMBL14924437 | 0.76 | SLC6A2 (0.42) | SIGMAR1DRD2DRD4SLC6A4 | |
| SCHEMBL22542093 | 0.75 | DRD4 (0.45) | DRD2DRD4DRD3 | |
| SCHEMBL22542097 | 0.74 | DRD2 (0.38) | SIGMAR1DRD2DRD4DRD3CCR5 | |
| SCHEMBL22542116 | 0.73 | DRD4 (0.45) | DRD2DRD4DRD3 | |
| SCHEMBL8289625 | 0.72 | CHRNB2 (0.41) | SIGMAR1NOS3NOS1NOS2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020210383-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | NUVATION BIO INC. (US) | 2020-10-15 | — | — | WO | disclosed |