Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.30 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL6035884 | 1.00 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL2293273 | 1.00 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL9818467 | 1.00 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL27664482 | 1.00 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL27656022 | 1.00 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Galactose SCHEMBL1904377 | 1.00 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL27794573 | 0.98 | USP2 (0.46) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL3393205 | 0.98 | USP2 (0.46) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL9751218 | 0.96 | USP2 (0.44) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Xylose SCHEMBL10181263 | 0.94 | USP2 (0.44) | USP2SLCO1B1PDE4ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101785577-B | Method for reducing irritation of papermaking-method tobacco sheets | CHINA TOBACCO HUBEI IND LLC | 2012-02-29 | — | — | CN | claimed |
| CN-101785577-A | Method for reducing irritation of papermaking-method tobacco sheets | CHINA TOBACCO HUBEI IND LLC | 2010-07-28 | — | — | CN | claimed |
| EP-4346793-A1 | AMINO ACID HYDRATION FORMULATION AND METHOD OF USE | The Coca-Cola Company (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-115777918-A | High molecular weight melanoidin, preparation method thereof and application of melanoidin in reducing Maillard reaction hazards | 华南理工大学 | 2023-03-14 | — | — | CN | disclosed |
| CN-111269164-B | Ketone compound, preparation method and application thereof, and method for site-directed modification of protein containing cysteine residues or disulfide bonds | 南开大学 | 2021-11-02 | — | — | CN | disclosed |
| CN-107889939-B | Glycine glucose extracellular polysaccharide compound feed additive | 福建九为生物技术有限公司 | 2020-12-25 | — | — | CN | disclosed |
| CN-107889939-B | Glycine glucose extracellular polysaccharide compound feed additive | 福建九为生物技术有限公司 | 2020-12-25 | — | — | CN | disclosed |
| CN-107889939-B | Glycine glucose extracellular polysaccharide compound feed additive | 福建九为生物技术有限公司 | 2020-12-25 | — | — | CN | disclosed |
| EP-3723728-A1 | INJECTABLE SOLUTION WITH A PH OF 7 COMPRISING AT LEAST ONE BASAL INSULIN WITH A PI OF BETWEEN 5.8 AND 8.5 AND A CO-POLYAMINOACID BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS | Adocia (FR) | 2020-10-21 | — | — | EP | disclosed |
| CN-111269164-A | Ketone compound, preparation method and application thereof, and method for site-directed modification of protein containing cysteine residues or disulfide bonds | 南开大学 | 2020-06-12 | — | — | CN | disclosed |
| CN-110452185-A | Fluorine-containing coupling agent and preparation method and application thereof | SICHUAN UNIV OF SCIENCE & ENGINEERING CO LTD | 2019-11-15 | — | — | CN | disclosed |
| CN-107889939-A | A kind of glycine glucose exocellular polysaccharide compound feed additive | 福建九为生物技术有限公司 | 2018-04-10 | — | — | CN | disclosed |
| CN-107889939-A | A kind of glycine glucose exocellular polysaccharide compound feed additive | 福建九为生物技术有限公司 | 2018-04-10 | — | — | CN | disclosed |
| CN-107048421-A | A kind of preparation method of anti-oxidant microcapsule wall material | 常州大学 | 2017-08-18 | — | — | CN | disclosed |
| CN-106467562-A | A kind of aminoacid sugar ester, its preparation method and its application | 中石化石油工程技术服务有限公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-103583829-B | The preparation method of the flavouring agent of feed or pet food | SHANGHAI MENON ANIMAL NUTRITION TECHNOLOGY CO., LTD. (CN) | 2015-08-05 | — | — | CN | disclosed |
| CN-103583829-A | Preparation method for flavoring agent of feed or pet food | SHANGHAI MEINONG BIOTECHNOLOGY CO LTD | 2014-02-19 | — | — | CN | disclosed |
| CN-101785577-B | Method for reducing irritation of papermaking-method tobacco sheets | CHINA TOBACCO HUBEI IND LLC | 2012-02-29 | — | — | CN | disclosed |
| CN-101785577-A | Method for reducing irritation of papermaking-method tobacco sheets | CHINA TOBACCO HUBEI IND LLC | 2010-07-28 | — | — | CN | disclosed |
| CN-101080238-A | Compositions and methods for the preparation of human growth hormone glycosylation mutants | NEOSE TECHNOLOGIES INC (US) | 2007-11-28 | — | — | CN | disclosed |