Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.30 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL6035884 | 1.00 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL2293273 | 1.00 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL9818467 | 1.00 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL27656022 | 1.00 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL22551090 | 1.00 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Galactose SCHEMBL1904377 | 1.00 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL27794573 | 0.98 | USP2 (0.46) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL3393205 | 0.98 | USP2 (0.46) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL9751218 | 0.96 | USP2 (0.44) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Xylose SCHEMBL10181263 | 0.94 | USP2 (0.44) | USP2SLCO1B1PDE4ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1969947-A | Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, preparation process and quality control method thereof | BEIJING QI YUAN YI PHARM RES (CN) | 2007-05-30 | — | — | CN | disclosed |
| CN-1969946-A | Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, preparation process and quality control method thereof | BEIJING QI YUAN YI PHARM RES (CN) | 2007-05-30 | — | — | CN | disclosed |
| CN-1954821-A | Traditional Chinese composite preparation for treating asthma and its preparation method | BEIJING QIYUAN YIDE MEDICAL IN (CN) | 2007-05-02 | — | — | CN | disclosed |
| CN-1954852-A | Chinese drugs compound preparation for treating asthma and its preparation method | BEIJING QIYUAN YIDE MEDICAL IN (CN) | 2007-05-02 | — | — | CN | disclosed |
| CN-1954857-A | Traditional Chinese medicinal compound preparation for treating asthma and its preparation method | BEIJING QIYUAN YIDE MEDICAL IN (CN) | 2007-05-02 | — | — | CN | disclosed |
| CN-1954850-A | Traditional Chinese medicinal compound preparation for treating asthma and its preparation method | BEIJING QIYUAN YIDE MEDICAL IN (CN) | 2007-05-02 | — | — | CN | disclosed |
| CN-1954854-A | Traditional Chinese medicinal compound preparation for treating asthma and its preparation method | BEIJING QIYUAN YIDE MEDICAL IN (CN) | 2007-05-02 | — | — | CN | disclosed |
| CN-1954858-A | Traditional Chinese medicinal compound preparation for treating asthma and its preparation method | BEIJING QIYUAN YIDE MEDICAL IN (CN) | 2007-05-02 | — | — | CN | disclosed |
| CN-1954851-A | Traditional Chinese medicinal compound preparation for treating asthma and its preparation method | BEIJING QIYUAN YIDE MEDICAL IN (CN) | 2007-05-02 | — | — | CN | disclosed |
| CN-1943715-A | A Chinese traditional medicinal injection preparation and its preparation method | QIYUAN YIDE MEDICINE INST BEIJ (CN) | 2007-04-11 | — | — | CN | disclosed |
| CN-1911372-A | Injection contg. traditional Chinese medicine, and its prepn. method | UNION XICHUANG PHARMACEUTICAL (CN) | 2007-02-14 | — | — | CN | disclosed |
| CN-1911370-A | Injection contg. traditional Chinese medicine, and its prepn. method | UNION XICHUANG PHARMACEUTICAL (CN) | 2007-02-14 | — | — | CN | disclosed |
| CN-1911368-A | Injection contg. traditional Chinese medicine, and its prepn. method | UNION XICHUANG PHARMACEUTICAL (CN) | 2007-02-14 | — | — | CN | disclosed |
| CN-1911371-A | Injection contg. traditional Chinese medicine, and its prepn. method | UNION XICHUANG PHARMACUTICAL S (CN) | 2007-02-14 | — | — | CN | disclosed |
| CN-1911367-A | Injection contg. traditional Chinese medicine, and its prepn. method | UNION XICHUANG PHARMACEUTICAL (CN) | 2007-02-14 | — | — | CN | disclosed |
| CN-1911375-A | Injection contg. traditional Chinese medicine, and its prepn. method | UNION XICHUANG PHARMACEUTICAL (CN) | 2007-02-14 | — | — | CN | disclosed |
| CN-1911390-A | Injection contg. traditional Chinese medicine, and its prepn. method | UNION XICHUANG PHARMACEUTICAL (CN) | 2007-02-14 | — | — | CN | disclosed |
| CN-1911377-A | Injection contg. traditional Chinese medicine, and its prepn. method | UNION XICHUANG PHARMACEUTICAL (CN) | 2007-02-14 | — | — | CN | disclosed |
| CN-1911392-A | Injection contg. traditional Chinese medicine, and its prepn. method | UNION XICHUANG PHARMACEUTICAL (CN) | 2007-02-14 | — | — | CN | disclosed |
| CN-1911369-A | Injection contg. traditional Chinese medicine, and its prepn. method | UNION XICHUANG PHARMACEUTICAL (CN) | 2007-02-14 | — | — | CN | disclosed |