Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL27794573 | 1.00 | USP2 (0.46) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL27664482 | 0.98 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL2293273 | 0.98 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL9818467 | 0.98 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Galactose SCHEMBL1904377 | 0.98 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL22551090 | 0.98 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL6035884 | 0.98 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL27656022 | 0.98 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL9751218 | 0.95 | USP2 (0.44) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Xylose SCHEMBL10181263 | 0.92 | USP2 (0.44) | USP2SLCO1B1PDE4ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109906269-B | Yeast strain saccharomyces cerevisiae subspecies eucalyptus DBVPG36P, application thereof in food fermentation production and method for selecting strain | 拜恩洛基2.0有限公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-2195416-B1 | MODIFIED INDUSTRIAL YEAST STRAINS | AUSTRALIAN WINE RES INST LTD (AU) | 2016-05-04 | — | — | EP | disclosed |
| US-8455216-B2 | Compositions and methods for reducing H2S levels in fermented beverages | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-06-04 | — | — | US | disclosed |
| US-20130071542-A1 | COMPOSITIONS AND METHODS FOR REDUCING H2S LEVELS IN FERMENTED BEVERAGES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-03-21 | — | — | US | disclosed |
| US-8389033-B2 | Modified industrial yeast strains | THE AUSTRALIAN WINE RESEARCH INSTITUTE LTD (AU) | 2013-03-05 | — | — | US | disclosed |
| EP-2132318-B1 | COMPOSITIONS AND METHODS FOR REDUCING H2S LEVELS IN FERMENTED BEVERAGES | UNIV CALIFORNIA (US) | 2012-08-22 | — | — | EP | disclosed |
| US-8216803-B2 | Compositions and methods for reducing H2S levels in fermented beverages | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-10 | — | — | US | disclosed |
| EP-2195416-A1 | MODIFIED INDUSTRIAL YEAST STRAINS | The Australian Wine Research Institute (AU) | 2010-06-16 | — | — | EP | disclosed |
| US-20100143536-A1 | COMPOSITIONS AND METHODS FOR REDUCING H2S LEVELS IN FERMENTED BEVERAGES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-06-10 | — | — | US | disclosed |
| EP-2132318-A2 | COMPOSITIONS AND METHODS FOR REDUCING H2S LEVELS IN FERMENTED BEVERAGES | The Regents of the University of California (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2009046485-A1 | MODIFIED INDUSTRIAL YEAST STRAINS | THE AUSTRALIAN WINE RESEARCH INSTITUTE LTD (AU) | 2009-04-16 | — | — | WO | disclosed |
| WO-2008115759-A2 | COMPOSITIONS AND METHODS FOR REDUCING H2S LEVELS IN FERMENTED BEVERAGES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-09-25 | — | — | WO | disclosed |