Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL9818467 | 0.96 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL2293273 | 0.96 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL6035884 | 0.96 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Galactose SCHEMBL1904377 | 0.96 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL22551090 | 0.96 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL27664482 | 0.96 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL27656022 | 0.96 | USP2 (0.47) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL27794573 | 0.95 | USP2 (0.46) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL3393205 | 0.95 | USP2 (0.46) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Demannose SCHEMBL9751344 | 0.94 | USP2 (0.40) | USP2SLCO1B1PDE4ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365560-A4 | RIBOFLAVIN PRODUCING STRAINS OF MICROORGANISMS, METHOD FOR SELECTING, AND METHOD FOR FERMENTATION | — | 1991-06-26 | — | — | EP | disclosed |
| EP-0365560-A1 | RIBOFLAVIN PRODUCING STRAINS OF MICROORGANISMS, METHOD FOR SELECTING, AND METHOD FOR FERMENTATION. | COORS BIOTECH INC (US) | 1990-05-02 | — | — | EP | disclosed |
| WO-1988009822-A1 | RIBOFLAVIN PRODUCING STRAINS OF MICROORGANISMS, METHOD FOR SELECTING, AND METHOD FOR FERMENTATION | COORS BIOTECH, INC. (US) | 1988-12-15 | — | — | WO | disclosed |