Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 11/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2252782 | 0.86 | CRHR1 (0.47) | CRHR1TSHRHSD17B10KDM4EALDH1A1 | |
| SCHEMBL1660741 | 0.76 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL1924190 | 0.74 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL2255140 | 0.73 | CRHR1 (0.47) | CRHR1POLB | |
| SCHEMBL12731289 | 0.71 | CRHR1 (0.39) | CRHR1TSHRHSD17B10TP53KDM4E | |
| SCHEMBL5447883 | 0.68 | CRHR1 (0.86) | CRHR1 | |
| SCHEMBL14491028 | 0.68 | CRHR1 (0.86) | CRHR1 | |
| SCHEMBL11904081 | 0.68 | TP53 (0.40) | CRHR1HSD17B10TP53KDM4EALDH1A1 | |
| SCHEMBL1237773 | 0.68 | CRHR1 (0.65) | CRHR1TSHRHSD17B10TP53KDM4E | |
| SCHEMBL12731288 | 0.68 | TSHR (0.39) | CRHR1TSHRHSD17B10TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994203-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-08-09 | — | — | US | disclosed |
| US-20100035874-A1 | Organic compounds | NOVARTIS AG (CH) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035874-A1 | Organic compounds | CRH, CRHR1, CRHR2 | CRHR1 2/4885TSHR 297/4885HSD17B10 2533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.