Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 14/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2252782 | 0.86 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL1924208 | 0.84 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL2261342 | 0.76 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL2256332 | 0.75 | TACR2 (0.45) | CRHR1 | |
| SCHEMBL2255257 | 0.75 | ALDH1A1 (0.32) | CRHR1 | |
| SCHEMBL2258421 | 0.73 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL2255241 | 0.73 | CRHR1 (0.50) | CRHR1POLB | |
| SCHEMBL1237267 | 0.72 | CRHR1 (0.67) | CRHR1 | |
| SCHEMBL2255193 | 0.71 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL1924190 | 0.71 | CRHR1 (0.49) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994203-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-08-09 | — | — | US | disclosed |
| US-20100035874-A1 | Organic compounds | NOVARTIS AG (CH) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035874-A1 | Organic compounds | CRH, CRHR1, CRHR2 | CRHR1 2/4885HSP90AA1 2748/4885HSP90AB1 3076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.