Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.53 |
| ▸ | ELANE | P08246 | 11/20 | 0.51 |
| ▸ | EP300 | Q09472 | 2/20 | 0.51 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30064961 | 1.00 | IDO1 (0.53) | IDO1ELANEEP300KAT8ALDH1A1 | |
| SCHEMBL16005349 | 0.83 | ELANE (0.54) | IDO1ELANEEP300KAT8ALDH1A1 | |
| SCHEMBL18785662 | 0.81 | ELANE (0.53) | IDO1ELANECHEK1 | |
| SCHEMBL28298353 | 0.80 | PKM (0.62) | ELANELMNACHEK1PKMNPC1 | |
| SCHEMBL28841735 | 0.79 | IDO1 (0.55) | IDO1EP300KAT8ALDH1A1LMNA | |
| SCHEMBL30341823 | 0.77 | PKM (0.49) | ELANEALDH1A1LMNAPKMNPC1 | |
| SCHEMBL12643226 | 0.77 | IDO1 (0.53) | IDO1ELANEEP300KAT8ALDH1A1 | |
| SCHEMBL19180363 | 0.77 | PKM (0.67) | IDO1EP300KAT8LMNAPKM | |
| SCHEMBL31748924 | 0.76 | ALDH1A1 (0.60) | ELANEALDH1A1TSHRRAB9A | |
| SCHEMBL1538258 | 0.76 | ALDH1A1 (0.60) | ELANEALDH1A1TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548888-B2 | KRas G12C inhibitors | Mirati Therapeutics, Inc. (US) | 2023-01-10 | — | — | US | disclosed |
| US-20200331911-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. | 2020-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11548888-B2 | KRas G12C inhibitors | KRAS, NRAS, HRAS | IDO1 4640/4885ELANE 1876/4885EP300 2307/4885 |
| US-20200331911-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | IDO1 4640/4885ELANE 1876/4885EP300 2307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.