Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 1/20 | 0.47 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 2/20 | 0.37 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL223453 | 0.86 | LPL (0.50) | LPLLIPGRARBRARARARG | |
| SCHEMBL1533781 | 0.82 | LPL (0.47) | LPLLIPGRXRARXRBFAAH | |
| SCHEMBL19384703 | 0.81 | RARB (0.60) | LPLLIPGRARBRARARARG | |
| SCHEMBL23512339 | 0.79 | ESR1 (0.47) | RXRARXRBFAAHRARBRARA | |
| SCHEMBL15196005 | 0.79 | CA2 (0.41) | LPLLIPGCYP11B1CYP11B2ESR1 | |
| SCHEMBL16258125 | 0.79 | TAAR1 (0.41) | RXRARXRBFAAHRARBRARA | |
| SCHEMBL8862226 | 0.79 | TAAR1 (0.41) | RXRARXRBFAAHRARBRARA | |
| SCHEMBL16104441 | 0.79 | TAAR1 (0.41) | RXRARXRBFAAHRARBRARA | |
| SCHEMBL19844719 | 0.77 | TAAR1 (0.40) | RXRARXRBFAAHRARBRARA | |
| SCHEMBL26036251 | 0.77 | CHKA (0.42) | RXRARXRBFAAHRARBRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107011920-B | Liquid-crystalline medium comprising thiophene derivatives | 默克专利股份有限公司 | 2021-06-22 | — | — | CN | disclosed |
| EP-2598604-B1 | LIQUID CRYSTAL MEDIUM CONTAINING THIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-11-25 | — | — | EP | disclosed |
| US-8906261-B2 | Liquid crystal medium containing thiophene derivatives | MERCK PATENT GMBH (DE) | 2014-12-09 | — | — | US | disclosed |
| US-8486297-B2 | Thiophene derivatives, and LC media comprising same | MERCK PATENT GMBH (DE) | 2013-07-16 | — | — | US | disclosed |
| EP-2598604-A1 | LIQUID CRYSTAL MEDIUM CONTAINING THIOPHENE DERIVATIVES | Merck Patent GmbH (DE) | 2013-06-05 | — | — | EP | disclosed |
| US-20130119312-A1 | LIQUID CRYSTAL MEDIUM CONTAINING THIOPHENE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-05-16 | — | — | US | disclosed |
| EP-2398787-B1 | Thiophene derivates and liquid crystal media comprising the same | MERCK PATENT GMBH (DE) | 2013-01-30 | — | — | EP | disclosed |
| WO-2012013281-A1 | LIQUID CRYSTAL MEDIUM CONTAINING THIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-02-02 | — | — | WO | disclosed |
| US-20120001123-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA COMPRISING SAME | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-01-05 | — | — | US | disclosed |
| EP-2398787-A1 | THIOPHENE DERIVATES AND LIQUID CRYSTAL MEDIA COMPRISING THE SAME | Merck Patent GmbH (DE) | 2011-12-28 | — | — | EP | disclosed |
| WO-2010099853-A1 | THIOPHENE DERIVATES AND LIQUID CRYSTAL MEDIA COMPRISING THE SAME | MERCK PATENT GMBH (DE) | 2010-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120001123-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA COMPRISING SAME | TEC, TPMT, TST | LPL 86/4885LIPG 477/4885RXRA 3644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.