SCHEMBL22558028

SCHEMBL22558028

Cc1c(C(=O)O)c(Br)nn1-c1ncccc1Cl

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.40
MYC P01106 1/20 0.40
MALT1 Q9UDY8 2/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
HDAC9 Q9UKV0 1/20 0.38
KDM4E B2RXH2 1/20 0.38
GAA P10253 1/20 0.37
DHODH Q02127 2/20 0.36
HSD11B1 P28845 1/20 0.36
PDE4B Q07343 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
POLB P06746 1/20 0.35
CYP17A1 P05093 1/20 0.35
CYP1A2 P05177 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29437214 1.00 LMNA (0.40) LMNAMYCMALT1MEN1KMT2A
SCHEMBL29437215 0.85 PDE4B (0.54) LMNAKDM4EGAAHSD11B1PDE4B
SCHEMBL22558023 0.85 PDE4B (0.54) LMNAKDM4EGAAHSD11B1PDE4B
SCHEMBL29437212 0.85 PDE4B (0.54) LMNAKDM4EGAAHSD11B1PDE4B
SCHEMBL21822480 0.78 MALT1 (0.38) LMNAMYCMALT1MEN1KMT2A
SCHEMBL27912745 0.78 MALT1 (0.38) LMNAMYCMALT1DHODHSMN1; SMN2
Hydrochloric Acid SCHEMBL28899877 0.77 MALT1 (0.38) LMNAMYCMALT1DHODHSMN1; SMN2
SCHEMBL29232359 0.76 MALT1 (0.35) LMNAMYCMALT1MEN1KMT2A
SCHEMBL15122139 0.76 SLC22A12 (0.38) MYCMALT1
SCHEMBL28824119 0.75 KDM4E (0.36) LMNAMYCMALT1KDM4EDHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12459913-B2 Preparation of substituted pyrazoles and their use as anthranilamides precursors ADAMA MAKHTESHIM LTD. (IL) 2025-11-04 US disclosed
US-20220177444-A1 PREPARATION OF SUBSTITUTED PYRAZOLES AND THEIR USE AS ANTHRANILAMIDES PRECURSORS ADAMA MAKHTESHIM LTD. (IL) 2022-06-09 US disclosed
US-20220177444-A1 PREPARATION OF SUBSTITUTED PYRAZOLES AND THEIR USE AS ANTHRANILAMIDES PRECURSORS ADAMA MAKHTESHIM LTD. (IL) 2022-06-09 US disclosed
EP-3956314-A1 PREPARATION OF SUBSTITUTED PYRAZOLES AND THEIR USE AS ANTHRANILAMIDES PRECURSORS Adama Makhteshim Ltd. (IL) 2022-02-23 EP disclosed
CN-113874356-A Preparation of substituted pyrazoles and their use as anthranilamide precursors 安道麦马克西姆有限公司 2021-12-31 CN disclosed
CN-111825653-A Preparation of substituted pyrazoles and use thereof as anthranilamide precursors 安道麦马克西姆有限公司 2020-10-27 CN disclosed
WO-2020212991-A1 PREPARATION OF SUBSTITUTED PYRAZOLES AND THEIR USE AS ANTHRANILAMIDES PRECURSORS ADAMA MAKHTESHIM LTD. (IL) 2020-10-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220177444-A1 PREPARATION OF SUBSTITUTED PYRAZOLES AND THEIR USE AS ANTHRANILAMIDES PRECURSORS CYP2F1, PPOX, CYP11B2 LMNA 2820/4885MYC 3659/4885MALT1 2465/4885
US-12459913-B2 Preparation of substituted pyrazoles and their use as anthranilamides precursors CYP2F1, PPOX, CYP11B2 LMNA 2820/4885MYC 3659/4885MALT1 2465/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.