SCHEMBL22562250

SCHEMBL22562250

CC(C)(C)c1ccc2c(c1)c1ccccc1n2-c1cc(C#N)c(-c2cccc(-c3ccccc3)n2)cc1-n1c2ccccc2c2cc(C(C)(C)C)ccc21

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRG2 P18507 2/20 0.34
GABRB3 P28472 2/20 0.34
GABRA5 P31644 2/20 0.34
GABRA3 P34903 2/20 0.34
GABRA1 P14867 1/20 0.34
SLC22A12 Q96S37 4/20 0.34
CTSS P25774 1/20 0.33
CTSK P43235 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MAPT P10636 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
SQOR Q9Y6N5 1/20 0.33
MEN1 O00255 1/20 0.33
RAB9A P51151 1/20 0.33
KMT2A Q03164 1/20 0.33
ABCG2 Q9UNQ0 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562251 0.95 KDM4E (0.33) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL22562248 0.92 NPSR1 (0.34) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL22562425 0.91 CTSS (0.41) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL19909533 0.91 SQOR (0.36) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL21278735 0.89 ABCG2 (0.36) GABRG2GABRB3GABRA5GABRA3SLC22A12
SCHEMBL23487796 0.89 SQOR (0.36) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL22562445 0.88 KDM4E (0.41) KDM4EMAPTL3MBTL1CYP1A2CYP2C9
SCHEMBL22562429 0.88 CTSS (0.44) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL22562293 0.87 CYP11B1 (0.36) GABRG2GABRB3GABRA5GABRA3KDM4E
SCHEMBL19919435 0.87 GABRG2 (0.38) GABRG2GABRB3GABRA5GABRA3GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed