SCHEMBL22562425

SCHEMBL22562425

N#Cc1cc(-n2c3ccccc3c3cc(C(F)(F)F)ccc32)c(-n2c3ccccc3c3cc(C(F)(F)F)ccc32)cc1-c1cccc(-c2ccccc2)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 2/20 0.41
SCN9A Q15858 1/20 0.36
XDH P47989 1/20 0.35
KIF11 P52732 1/20 0.34
ALOX5AP P20292 1/20 0.34
FEN1 P39748 1/20 0.34
PPARG P37231 2/20 0.33
PPARA Q07869 2/20 0.33
GABRG2 P18507 2/20 0.33
GABRB3 P28472 2/20 0.33
GABRA3 P34903 2/20 0.33
GABRA1 P14867 1/20 0.33
CDK2 P24941 1/20 0.33
GSK3B P49841 1/20 0.33
TOP1 P11387 1/20 0.33
CNR2 P34972 1/20 0.33
CYP11B1 P15538 1/20 0.33
CYP11B2 P19099 1/20 0.33
KDM4E B2RXH2 1/20 0.33
TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562429 0.97 CTSS (0.44) CTSSSCN9AXDHALOX5APFEN1
SCHEMBL22562349 0.94 CTSS (0.41) CTSSSCN9AXDHKIF11ALOX5AP
SCHEMBL22562423 0.94 CTSS (0.41) CTSSSCN9AXDHKIF11ALOX5AP
SCHEMBL22562606 0.91 CTSS (0.36) CTSSSCN9AXDHALOX5APFEN1
SCHEMBL19909073 0.91 KIF11 (0.35) CTSSXDHKIF11ALOX5APFEN1
SCHEMBL22562250 0.91 GABRG2 (0.34) CTSSPPARGGABRG2GABRB3GABRA3
SCHEMBL22562428 0.91 CTSS (0.44) CTSSSCN9AXDHKIF11ALOX5AP
SCHEMBL21278862 0.89 LMNA (0.36) CTSSKIF11ALOX5APFEN1TOP1
SCHEMBL22563397 0.89 KIF11 (0.35) CTSSXDHKIF11ALOX5APFEN1
SCHEMBL22562343 0.88 CTSS (0.41) CTSSSCN9AXDHKIF11ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed