SCHEMBL22562435

SCHEMBL22562435

Cc1cc(C)cc(-c2ccc3c(c2)c2cc(-c4cc(C)cc(C)c4)ccc2n3-c2cc(C#N)cc(-n3c4ccc(-c5cc(C)cc(C)c5)cc4c4cc(-c5cc(C)cc(C)c5)ccc43)c2-c2cccc(C)n2)c1

nearest known ligand 0.44

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 4/20 0.37
GRM5 P41594 2/20 0.34
IRAK4 Q9NWZ3 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562583 0.89 ALDH1A3 (0.39) GRM5
SCHEMBL22562561 0.89 TGFBR1 (0.38) TGFBR1
SCHEMBL22562436 0.88 TGFBR1 (0.37) TGFBR1GRM5IRAK4
SCHEMBL22562417 0.87 CTSS (0.36) TGFBR1GRM5
SCHEMBL22562559 0.84 TGFBR1 (0.36) TGFBR1IRAK4
SCHEMBL21546620 0.83 CYP1A2 (0.39) TGFBR1GRM5
SCHEMBL21279099 0.82 MEN1 (0.38) GRM5
SCHEMBL19909397 0.82 MYC (0.40) GRM5
SCHEMBL22563480 0.82 ALDH1A3 (0.38) GRM5
SCHEMBL22562558 0.82 HSD11B1 (0.37) TGFBR1IRAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed