SCHEMBL22562476

SCHEMBL22562476

FC(F)(F)c1ccc2c(c1)c1ccccc1n2-c1cc(-c2cccc(-c3ccccc3)n2)cc(-n2c3ccccc3c3cc(C(F)(F)F)ccc32)c1C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.39
DHODH Q02127 1/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
RAB9A P51151 2/20 0.36
NPC1 O15118 2/20 0.36
ATM Q13315 1/20 0.36
LMNA P02545 2/20 0.36
ALDH1A1 P00352 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
MAPT P10636 2/20 0.36
CTSS P25774 1/20 0.36
TDP1 Q9NUW8 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
PTGER1 P34995 1/20 0.35
ESR1 P03372 1/20 0.35
ADORA2A P29274 1/20 0.34
ADORA1 P30542 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562353 0.96 RAB9A (0.39) DHODHMEN1KMT2ARAB9ANPC1
SCHEMBL22562245 0.93 PPARG (0.35) KIF11DHODHMEN1KMT2ARAB9A
SCHEMBL22562477 0.93 KIF11 (0.44) KIF11DHODHMEN1KMT2ARAB9A
SCHEMBL22562264 0.93 KIF11 (0.35) KIF11DHODHMEN1KMT2ARAB9A
SCHEMBL22562265 0.90 MEN1 (0.37) MEN1KMT2ARAB9AATMLMNA
SCHEMBL22562607 0.90 MEN1 (0.37) MEN1KMT2ARAB9AATMLMNA
SCHEMBL22562478 0.90 MAT2A (0.41) KIF11DHODHMEN1KMT2ARAB9A
SCHEMBL22562222 0.89 ALOX5AP (0.37) KIF11DHODHMEN1KMT2ANPC1
SCHEMBL22562244 0.88 KIF11 (0.39) KIF11DHODHMEN1KMT2ARAB9A
SCHEMBL22562371 0.88 MEN1 (0.36) DHODHMEN1KMT2ARAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed