SCHEMBL22562222

SCHEMBL22562222

FC(F)(F)c1ccc(-c2ccc3c(c2)c2ccccc2n3-c2cc(-c3cccc(-c4ccccc4)n3)cc(-n3c4ccccc4c4cc(-c5ccc(C(F)(F)F)cc5C(F)(F)F)ccc43)c2C(F)(F)F)c(C(F)(F)F)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 1/20 0.37
FEN1 P39748 1/20 0.37
CYP2C9 P11712 1/20 0.36
SCN9A Q15858 1/20 0.36
EDNRB P24530 1/20 0.36
EDNRA P25101 1/20 0.36
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34
KMT2A Q03164 1/20 0.34
ATM Q13315 1/20 0.34
AKR1C3 P42330 1/20 0.33
AKR1C2 P52895 1/20 0.33
TRPA1 O75762 1/20 0.33
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33
KIF11 P52732 1/20 0.33
TOP1 P11387 2/20 0.32
DHODH Q02127 1/20 0.32
CYP11B2 P19099 1/20 0.32
S1PR1 P21453 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562557 0.97 ALOX5AP (0.39) ALOX5APFEN1CYP2C9SCN9AEDNRB
SCHEMBL22562553 0.91 ALOX5AP (0.39) ALOX5APFEN1CYP2C9SCN9AEDNRB
SCHEMBL22562589 0.90 ALOX5AP (0.37) ALOX5APFEN1CYP2C9SCN9AEDNRB
SCHEMBL22562391 0.89 CTSS (0.37) ALOX5APFEN1CYP2C9SCN9AEDNRB
SCHEMBL22562476 0.89 KIF11 (0.39) CYP2C9MEN1NPC1KMT2AATM
SCHEMBL19942801 0.89 S1PR1 (0.36) ALOX5APFEN1CYP2C9SCN9AEDNRB
SCHEMBL22562613 0.86 ALOX5AP (0.39) ALOX5APFEN1CYP2C9SCN9AEDNRB
SCHEMBL22562527 0.86 CTSS (0.39) ALOX5APFEN1CYP2C9SCN9AEDNRB
SCHEMBL22562353 0.86 RAB9A (0.39) CYP2C9MEN1NPC1KMT2AADORA2A
SCHEMBL21108431 0.85 S1PR1 (0.38) ALOX5APFEN1CYP2C9SCN9AEDNRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed