SCHEMBL22562528

SCHEMBL22562528

N#Cc1c(-n2c3cc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)ccc3c3ccc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)cc32)cc(-c2cccc(-c3ccccc3)n2)cc1-n1c2cc(-c3ccc(C(F)(F)F)cc3C(F)(F)F)ccc2c2ccc(-c3ccc(C(F)(F)F)cc3C(F)(F)F)cc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 1/20 0.39
KDM4E B2RXH2 6/20 0.38
ALDH1A1 P00352 5/20 0.38
HPGD P15428 5/20 0.38
L3MBTL1 Q9Y468 3/20 0.38
TDP1 Q9NUW8 3/20 0.38
GAA P10253 2/20 0.38
ALOX5AP P20292 1/20 0.36
FEN1 P39748 1/20 0.36
CYP2C9 P11712 1/20 0.36
SCN9A Q15858 1/20 0.36
NPSR1 Q6W5P4 2/20 0.35
ADORA2A P29274 2/20 0.35
ADORA1 P30542 2/20 0.35
EDNRB P24530 1/20 0.35
EDNRA P25101 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
MAPT P10636 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
KMT2A Q03164 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562527 0.93 CTSS (0.39) CTSSKDM4EALDH1A1HPGDL3MBTL1
SCHEMBL22562391 0.92 CTSS (0.37) CTSSKDM4EALDH1A1HPGDL3MBTL1
SCHEMBL19909237 0.91 KDM4E (0.39) KDM4EALDH1A1HPGDL3MBTL1TDP1
SCHEMBL21279040 0.89 KDM4E (0.38) KDM4EALDH1A1HPGDL3MBTL1TDP1
SCHEMBL22562220 0.89 CTSS (0.45) CTSSKDM4EALDH1A1HPGDL3MBTL1
SCHEMBL22562195 0.89 METAP2 (0.36) CTSSKDM4EALDH1A1HPGDL3MBTL1
SCHEMBL22562553 0.89 ALOX5AP (0.39) KDM4EHPGDALOX5APFEN1CYP2C9
SCHEMBL23487685 0.88 KDM4E (0.38) KDM4EALDH1A1HPGDL3MBTL1TDP1
SCHEMBL21258769 0.87 ALDH1A1 (0.39) KDM4EALDH1A1HPGDL3MBTL1TDP1
SCHEMBL22562372 0.87 CTSS (0.38) CTSSKDM4EALDH1A1HPGDL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed