SCHEMBL22562601

SCHEMBL22562601

Cc1ccc2c(c1)c1ccccc1n2-c1cc(C(F)(F)F)c(-n2c3ccccc3c3cc(C)ccc32)cc1-c1cccc(-c2ccccc2)n1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.35
ALDH1A1 P00352 3/20 0.34
MAPT P10636 2/20 0.34
CYP11B2 P19099 2/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
KDM4E B2RXH2 2/20 0.34
LMNA P02545 1/20 0.34
RECQL P46063 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
ENPP1 P22413 1/20 0.34
CYP11B1 P15538 1/20 0.34
HSD11B1 P28845 2/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
NLRP3 Q96P20 1/20 0.33
RAB9A P51151 1/20 0.33
ESR1 P03372 1/20 0.32
HSD17B10 Q99714 1/20 0.32
PIM1 P11309 1/20 0.32
CDK4 P11802 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562592 0.93 PTGDR2 (0.35) PTGDR2ALDH1A1MAPTCYP11B2MEN1
SCHEMBL22562421 0.90 MAPT (0.39) ALDH1A1MAPTCYP11B2MEN1KMT2A
SCHEMBL22562491 0.90 CYP11B2 (0.38) CYP11B2MEN1KMT2ACYP11B1RAB9A
SCHEMBL22562594 0.89 ALDH1A1 (0.37) PTGDR2ALDH1A1MAPTCYP11B2MEN1
SCHEMBL22562490 0.89 KIF11 (0.36) CYP11B2MEN1KMT2ARAB9AESR1
SCHEMBL22562306 0.89 CYP11B2 (0.35) ALDH1A1CYP11B2MEN1KMT2AKDM4E
SCHEMBL22562329 0.87 CYP11B2 (0.36) ALDH1A1MAPTCYP11B2MEN1KMT2A
SCHEMBL22562426 0.87 CYP11B2 (0.36) MAPTCYP11B2MEN1KMT2AENPP1
SCHEMBL22562596 0.87 CYP11B2 (0.35) PTGDR2ALDH1A1MAPTCYP11B2MEN1
SCHEMBL22562496 0.86 CYP11B2 (0.40) CYP11B2MEN1KMT2ACYP11B1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed