Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 6/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22563033 | 0.86 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11TDP1 | |
| SCHEMBL17774964 | 0.68 | IKBKB (0.44) | RAPGEF4MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL22563010 | 0.66 | HDAC6 (0.37) | RAPGEF4MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3631643 | 0.65 | RAPGEF4 (0.59) | RAPGEF4ALDH1A1HDAC6MEN1KMT2A | |
| SCHEMBL4278475 | 0.65 | ALDH1A1 (0.72) | RAPGEF4ALDH1A1HDAC6 | |
| SCHEMBL16497558 | 0.65 | RAPGEF4 (0.79) | RAPGEF4ALDH1A1TDP1CYP3A4RECQL | |
| SCHEMBL22563186 | 0.64 | JAK1 (0.37) | ALDH1A1HDAC6MEN1KMT2A | |
| SCHEMBL29637676 | 0.63 | RAPGEF4 (0.79) | RAPGEF4ALDH1A1HDAC6CYP3A4ALOX15 | |
| SCHEMBL9799041 | 0.61 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL7169985 | 0.61 | CXCR2 (0.48) | RAPGEF4MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725777-A1 | BENZO- AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | Rottapharm Biotech S.r.l. (IT) | 2020-10-21 | — | — | EP | disclosed |