Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22563043 | 0.73 | ALDH1A1 (0.35) | MEN1KMT2ANPC1SMN1; SMN2HDAC1 | |
| SCHEMBL6717442 | 0.65 | KDM4E (0.54) | P4HTMMEN1KMT2A | |
| SCHEMBL28537077 | 0.65 | SMN1; SMN2 (0.50) | P4HTMMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL25605312 | 0.64 | PRKAB2 (0.43) | NPC1SMN1; SMN2RAB9A | |
| SCHEMBL22563017 | 0.63 | HDAC1 (0.37) | HDAC1HDAC3HDAC2NCOR2HDAC6 | |
| SCHEMBL27308949 | 0.60 | TAS1R3 (0.39) | MEN1KMT2ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL30763190 | 0.60 | SMN1; SMN2 (0.60) | P4HTMMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL21595582 | 0.60 | SMN1; SMN2 (0.60) | P4HTMMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL22116941 | 0.59 | GAA (0.50) | MEN1KMT2AAURKANPC1SMN1; SMN2 | |
| SCHEMBL20178617 | 0.58 | KDM4E (0.54) | P4HTMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725777-A1 | BENZO- AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | Rottapharm Biotech S.r.l. (IT) | 2020-10-21 | — | — | EP | disclosed |