SCHEMBL22571191

SCHEMBL22571191

CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(OC(=O)c2ccccc2)C1O

nearest known ligand 0.64

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ P2RX3 P56373 2/20 0.64
▸ P2RX4 Q99571 2/20 0.64
▸ P2RX2 Q9UBL9 2/20 0.64
▸ P2RY11 Q96G91 2/20 0.64
▸ P2RX6 O15547 1/20 0.64
▸ P2RX1 P51575 1/20 0.64
▸ P2RX5 Q93086 1/20 0.64
▸ P2RX7 Q99572 1/20 0.64
▸ ENPP1 P22413 1/20 0.58
▸ ADORA1 P30542 3/20 0.57
▸ NT5E P21589 1/20 0.53
▸ ABCB1 P08183 1/20 0.52
▸ GSK3A P49840 2/20 0.51
▸ RPS6KA3 P51812 2/20 0.51
▸ MAPK14 Q16539 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22571193 0.94 ENPP1 (0.66) P2RX3P2RX4P2RX2P2RY11P2RX6
SCHEMBL5797749 0.86 P2RX3 (0.66) P2RX3P2RX4P2RX2P2RY11P2RX6
SCHEMBL13046091 0.86 P2RX3 (0.66) P2RX3P2RX4P2RX2P2RY11P2RX6
SCHEMBL5797743 0.86 P2RX3 (0.66) P2RX3P2RX4P2RX2P2RY11P2RX6
SCHEMBL23002345 0.84 ADORA1 (0.57) P2RY11ADORA1
SCHEMBL21374103 0.84 ADORA1 (0.57) P2RY11ADORA1
SCHEMBL14565268 0.84 ADORA1 (0.57) P2RY11ADORA1
SCHEMBL15293693 0.84 ADORA1 (0.57) P2RY11ADORA1
SCHEMBL13388121 0.84 ADORA1 (0.57) P2RY11ADORA1
SCHEMBL14384200 0.84 ADORA1 (0.57) P2RY11ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11174279-B2 Method for synthesizing ribonucleic acid H-phosphonate monomer, and oligonucleotide synthesis in which said monomer is used NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2021-11-16 — — US disclosed
US-20200331945-A1 METHOD FOR SYNTHESIZING RIBONUCLEIC ACID H-PHOSPHONATE MONOMER, AND OLIGONUCLEOTIDE SYNTHESIS IN WHICH SAID MONOMER IS USED NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2020-10-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200331945-A1 METHOD FOR SYNTHESIZING RIBONUCLEIC ACID H-PHOSPHONATE MONOMER, AND OLIGONUCLEOTIDE SYNTHESIS IN WHICH SAID MONOMER IS USED RNGTT, RNASEL, NSUN3 P2RX3 2126/4885P2RX4 2142/4885P2RX2 2237/4885
US-11174279-B2 Method for synthesizing ribonucleic acid H-phosphonate monomer, and oligonucleotide synthesis in which said monomer is used RNGTT, RNASEL, NSUN3 P2RX3 2126/4885P2RX4 2142/4885P2RX2 2237/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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