Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 18/20 | 0.70 |
| ▸ | SLC27A2 | O14975 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24571215 | 0.88 | ADAMTS5 (0.67) | ADAMTS5SLC27A2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL22571237 | 0.88 | ADAMTS5 (0.81) | ADAMTS5SLC27A2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL24571119 | 0.88 | ADAMTS5 (0.74) | ADAMTS5SLC27A2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL24571121 | 0.85 | ADAMTS5 (0.78) | ADAMTS5SLC27A2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL24571266 | 0.83 | ADAMTS5 (0.73) | ADAMTS5SLC27A2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4355848 | 0.82 | ADAMTS5 (1.00) | ADAMTS5SLC27A2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL24571271 | 0.82 | ADAMTS5 (0.87) | ADAMTS5SLC27A2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL22571238 | 0.81 | ADAMTS5 (0.80) | ADAMTS5SLC27A2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL22571269 | 0.81 | ADAMTS5 (0.54) | ADAMTS5SLC27A2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL22571259 | 0.80 | ADAMTS5 (0.57) | ADAMTS5SLC27A2ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220202785-A1 | SMALL MOLECULE INHIBITORS OF GPCR GPR68 AND RELATED RECEPTORS FOR TREATING CANCER, GLIOBLASTOMA, AND OTHER INDICATIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-06-30 | — | — | US | disclosed |
| WO-2020214896-A1 | SMALL MOLECULE INHIBITORS OF GPCR GPR68 AND RELATED RECEPTORS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2020-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220202785-A1 | SMALL MOLECULE INHIBITORS OF GPCR GPR68 AND RELATED RECEPTORS FOR TREATING CANCER, GLIOBLASTOMA, AND OTHER INDICATIONS | GPR68, GPR65, GPR4 | ADAMTS5 3017/4885SLC27A2 1050/4885ALDH1A1 4359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.