Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 9/20 | 0.57 |
| ▸ | NPC1 | O15118 | 8/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22573749 | 0.91 | IDE (0.54) | ATMRAB9ANPC1KMT2APOLB | |
| SCHEMBL22573417 | 0.90 | KMT2A (0.59) | ATMRAB9ANPC1KMT2APOLB | |
| SCHEMBL22573696 | 0.86 | ATM (0.56) | ATMRAB9ANPC1KMT2APOLB | |
| SCHEMBL22573611 | 0.83 | NPC1 (0.56) | RAB9ANPC1KMT2APOLBALDH1A1 | |
| SCHEMBL22573501 | 0.83 | ADORA3 (0.60) | ATMRAB9ANPC1KMT2APOLB | |
| SCHEMBL22573633 | 0.82 | MEN1 (0.58) | RAB9ANPC1KMT2APOLBALDH1A1 | |
| SCHEMBL22573723 | 0.81 | RAB9A (0.59) | RAB9ANPC1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL22573570 | 0.81 | GRM5 (0.61) | ATMRAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL22573719 | 0.81 | LMNA (0.62) | RAB9ANPC1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL22573831 | 0.80 | ATR (0.64) | RAB9ANPC1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | disclosed |