Sugi Predict

Sugi Predict / Compounds / SCHEMBL22585593

SCHEMBL22585593

SCHEMBL22585593

CCC(O)c1ccc(Cl)s1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GABBR2 O75899 1/20 0.42
▸ GABBR1 Q9UBS5 1/20 0.42
▸ LMNA P02545 2/20 0.39
▸ KCNH2 Q12809 2/20 0.38
▸ CYP3A4 P08684 1/20 0.38
▸ CYP2D6 P10635 1/20 0.38
▸ SLC6A2 P23975 1/20 0.38
▸ SLC6A4 P31645 1/20 0.38
▸ SLC6A3 Q01959 1/20 0.38
▸ TOP2A P11388 1/20 0.37
▸ TOP2B Q02880 1/20 0.37
▸ WRN Q14191 1/20 0.36
▸ TSHR P16473 1/20 0.34
▸ GSK3B P49841 1/20 0.34
▸ F2 P00734 1/20 0.33
▸ DAO P14920 1/20 0.33
▸ CXCR1 P25024 1/20 0.33
▸ CXCR2 P25025 1/20 0.33
▸ MAPT P10636 3/20 0.32
▸ TP53 P04637 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23258012 1.00 GABBR2 (0.42) GABBR2GABBR1LMNAKCNH2CYP3A4
SCHEMBL11682799 0.88 GABBR2 (0.39) GABBR2GABBR1LMNAKCNH2CYP3A4
SCHEMBL14709152 0.81 GABBR2 (0.43) GABBR2GABBR1KCNH2CYP3A4CYP2D6
SCHEMBL5246292 0.81 GABBR2 (0.43) GABBR2GABBR1KCNH2CYP3A4CYP2D6
SCHEMBL5247316 0.81 GABBR2 (0.43) GABBR2GABBR1KCNH2CYP3A4CYP2D6
SCHEMBL27911200 0.81 GABBR2 (0.43) GABBR2GABBR1KCNH2CYP3A4CYP2D6
SCHEMBL5250926 0.81 GABBR2 (0.43) GABBR2GABBR1KCNH2CYP3A4CYP2D6
SCHEMBL17459297 0.79 GABBR2 (0.54) GABBR2GABBR1LMNAKCNH2CYP3A4
SCHEMBL20032385 0.78 GABBR2 (0.49) GABBR2GABBR1KCNH2CYP3A4CYP2D6
SCHEMBL21722780 0.78 GABBR2 (0.41) GABBR2GABBR1KCNH2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119343353-A 2-Methyl-4 ',5' -dihydrospiro [ piperidine-4, 7' -thieno [2,3-c ] pyran ] derivatives as APOL1 inhibitors and methods of use thereof 弗特克斯药品有限公司 2025-01-21 — — CN disclosed
CN-119013281-A 4',5' -Dihydrospiro [ piperidine-4, 7' -thieno [2,3-C ] pyran ] derivatives as APOL1 inhibitors and methods of use thereof 弗特克斯药品有限公司 2024-11-22 — — CN disclosed
CN-116547287-A Inhibitors of APOL1 and methods of use thereof 弗特克斯药品有限公司 2023-08-04 — — CN disclosed
US-20230086702-A1 SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A]PYRIDINE DERIVATIVES AND USE THEREOF BAYER AKTIENGESELLSCHAFT (DE) 2023-03-23 — — US disclosed
WO-2020215094-A1 SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A] PYRIDINE DERIVATIVES AND USE THEREOF THE JOHNS HOPKINS UNIVERSITY (US) 2020-10-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230086702-A1 SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A]PYRIDINE DERIVATIVES AND USE THEREOF SNCA, PSEN2, PRNP GABBR2 1726/4885GABBR1 1965/4885LMNA 1793/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.