Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16953181 | 0.87 | BACE1 (0.52) | ALDH1A1MAPK1MAPTKDM4ECYP3A4 | |
| SCHEMBL11849513 | 0.86 | ALDH1A1 (0.43) | ALDH1A1MAPK1MAPTKDM4ECYP3A4 | |
| SCHEMBL1572278 | 0.85 | ALDH1A1 (0.60) | ALDH1A1MAPK1MAPTKDM4ECYP3A4 | |
| SCHEMBL15938083 | 0.82 | CYP19A1 (0.51) | ALDH1A1MAPK1MAPTKDM4ECYP3A4 | |
| SCHEMBL15938082 | 0.82 | CYP19A1 (0.51) | ALDH1A1MAPK1MAPTKDM4ECYP3A4 | |
| SCHEMBL8842472 | 0.81 | CYP19A1 (0.50) | ALDH1A1MAPK1MAPTKDM4ECYP3A4 | |
| SCHEMBL227066 | 0.80 | TLR9 (0.60) | ALDH1A1MAPK1MAPTCYP19A1NPC1 | |
| SCHEMBL11745232 | 0.80 | CYP19A1 (0.72) | ALDH1A1MAPK1MAPTCYP19A1NPC1 | |
| SCHEMBL227065 | 0.80 | TLR9 (0.60) | ALDH1A1MAPK1MAPTCYP19A1NPC1 | |
| SCHEMBL11745227 | 0.80 | CYP19A1 (0.72) | ALDH1A1MAPK1MAPTCYP19A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111196778-B | Synthetic method of 3-ethylamino pyrrole compound | 郑州轻工业大学 | 2022-08-19 | — | — | CN | disclosed |
| CN-111196778-A | Synthetic method of 3-ethylamino pyrrole compound | 郑州轻工业大学 | 2020-05-26 | — | — | CN | disclosed |
| CN-107641086-B | Synthetic method of nitroolefin compound | 浙江工业大学 | 2020-05-22 | — | — | CN | disclosed |
| CN-107641086-A | A kind of synthetic method of nitro compds hydrocarbon compound | 浙江工业大学 | 2018-01-30 | — | — | CN | disclosed |
| EP-1577288-B1 | Selective estrogen receptor modulators | EISAI R&D MAN CO LTD (JP) | 2014-07-23 | — | — | EP | disclosed |
| US-8399520-B2 | Selective estrogen receptor modulator | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-03-19 | — | — | US | disclosed |
| US-20120004315-A1 | Selective Estrogen Receptor Modulator | RADIUS HEALTH, INC. | 2012-01-05 | — | — | US | disclosed |
| US-7960412-B2 | Selective estrogen receptor modulator | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-06-14 | — | — | US | disclosed |
| US-20090325930-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATOR | RADIUS HEALTH, INC. | 2009-12-31 | — | — | US | disclosed |
| US-7612114-B2 | Such as (R)-6-{2-{ethyl[4-(2-ethylaminoethyl)benzyl]amino }-4-methoxyphenyl }-5,6,7,8-tetrahydronaphthalen-2-ol; osteoporosis; breast cancer | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |
| EP-2109603-A1 | PROCESS FOR THE PREPARATION OF 8-HYDROXY-5-[(1R)-1-HYDROXY-2[[(1R)-2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]-ETHYL]-2(1H)-QUINOLINONE MONOHYDROCHLORIDE | CHIESI FARMACEUTICI S.p.A. (IT) | 2009-10-21 | — | — | EP | disclosed |
| WO-2008093188-A1 | PROCESS FOR THE PREPARATION OF 8-HYDROXY-5-[(1R)-1-HYDROXY-2[[(1R)-2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]-ETHYL]-2(1H)-QUINOLINONE MONOHYDROCHLORIDE | CHIESI FARMACEUTICI S.P.A. (IT) | 2008-08-07 | — | — | WO | disclosed |
| US-20060116364-A1 | Such as (R)-6-{2-{ethyl[4-(2-ethylaminoethyl)benzyl]amino }-4-methoxyphenyl }-5,6,7,8-tetrahydronaphthalen-2-ol; osteoporosis; breast cancer | EISAI CO., LTD. (JP) | 2006-06-01 | — | — | US | disclosed |
| EP-1577288-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATORS | Eisai Co., Ltd. (JP) | 2005-09-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325930-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATOR | ESR1, GPER1, ESR2 | ALDH1A1 1111/4885MAPK1 1484/4885MAPT 3989/4885 |
| US-20060116364-A1 | Such as (R)-6-{2-{ethyl[4-(2-ethylaminoethyl)benzyl]amino }-4-methoxyphenyl }-5,6,7,8-tetrahydronaphthalen-2-ol; osteoporosis; breast cancer | BRCA1, BCR, RCC1 | ALDH1A1 2275/4885MAPK1 1633/4885MAPT 2593/4885 |
| US-20120004315-A1 | Selective Estrogen Receptor Modulator | ESR1, GPER1, ESR2 | ALDH1A1 1214/4885MAPK1 1582/4885MAPT 3856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.