Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 6/20 | 0.43 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18270247 | 0.95 | CYP3A4 (0.48) | KCNH2CYP3A4ALDH1A1HPGDTDP1 | |
| SCHEMBL23509569 | 0.90 | KCNH2 (0.48) | KCNH2CYP3A4ALDH1A1HPGDTDP1 | |
| SCHEMBL24590554 | 0.90 | KCNH2 (0.46) | KCNH2CYP3A4ALDH1A1HPGDTDP1 | |
| SCHEMBL24943573 | 0.88 | FTO (0.57) | KCNH2HPGDTDP1SMN1; SMN2ALB | |
| SCHEMBL21973139 | 0.88 | KCNH2 (0.45) | KCNH2CYP3A4ALDH1A1HPGDTDP1 | |
| SCHEMBL29923596 | 0.85 | HPGD (0.46) | KCNH2CYP3A4ALDH1A1HPGDTDP1 | |
| SCHEMBL17056146 | 0.85 | HPGD (0.46) | KCNH2CYP3A4ALDH1A1HPGDTDP1 | |
| SCHEMBL15298989 | 0.85 | ALB (0.50) | KCNH2CYP3A4ALDH1A1HPGDTDP1 | |
| SCHEMBL17056160 | 0.84 | KCNH2 (0.43) | KCNH2CYP3A4ALDH1A1HPGDTDP1 | |
| SCHEMBL20353098 | 0.83 | KCNH2 (0.44) | KCNH2CYP3A4ALDH1A1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020219753-A1 | HEPARANASE COMPOUNDS AND METHODS OF USE | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2020-10-29 | — | — | WO | disclosed |